天然表面活性剂辅助制备羟基磷灰石材料研究  

Study on the preparation of hydroxyapatite materials assisted bynatural surfactants

作　　者：谷婉婷 董雨萱 刘彤 韩冰 詹舒辉 蒋建新 韩春蕊 宋杰 GU Wanting;DONG Yuxuan;LIU Tong;HAN Bing;ZHAN Shuhui;JIANG Jianxin;HAN Chunrui;SONG Jie(MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy, College of Materials Science and Technology, Beijing Forestry University, Beijing 100083, China;Key Laboratory of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China;College of Biology and Chemistry, University of Michigan(Flint), Michigan 48502, USA)

机构地区：[1]北京林业大学材料科学与技术学院,林业生物质材料与能源教育部工程研究中心,北京100083 [2]江苏省生物质能源与材料重点实验室,南京210042 [3]美国密西根大学(弗林特)生物与化学系,美国密西根州48502

出　　处：《功能材料》2021年第5期5195-5199,5220,共6页Journal of Functional Materials

基　　金：江苏省生物质能源与材料重点实验室开放基金资助项目(JSBEM201911);国家“十三五”重点研发计划资助项目(2016YFD0600803)。

摘　　要：羟基磷灰石(HAP)是稳定和生物相容性优良的骨修复和药物递送功能材料,其制备合成具有重要意义。以天然表面活性剂——无患子皂苷作为模板和修饰剂,采用水热法,制备得到蒲公英微球和纳米颗粒两种羟基磷灰石材料,并以X射线衍射(XRD)和扫描电镜(SEM)对材料的结构进行表征。考察了酸碱条件下皂苷浓度对材料形貌的影响,发现酸性条件下,随着皂苷浓度的增加,棒状结构变短,浓度增加到2g/L(10 CMC)时成长为蒲公英状聚集体,此时皂苷起到模板作用;碱性条件下起到修饰分散作用,材料趋于规整和均匀。为充分研究无患子皂苷在材料制备中的作用,采用GaussView软件对无患子皂苷的结构进行量子化学计算,得到最优构型和对静电分布图,推测无患子辅助制备HAP主要通过有机物和Ca2+之间的静电吸附作用,用作模板或修饰剂。该研究从量子化学等角度研究天然表面活性剂辅助制备HAP原理,不仅对HAP功能材料开发研究就有重要意义,也扩宽了天然表面活性剂在无机功能材料制备中的应用。Hydroxyapatite(HAP)is a stable and biocompatible functional material for bone repair and drug delivery.Two kinds of hydroxyapatite materials,dandelion microspheres and nanoparticles,are prepared by hydrothermal method with sapindoside as template and modifier.The structures of the materials are characterized by X-ray diffraction(XRD)and scanning electron microscopy(SEM).The effects of saponin concentration on the morphology of the materials are investigated.It is found that under acidic conditions,with the increase of saponin concentration,the rod-shaped structure becomes shorter.When the concentration increases to 2 g/L(10 CMC),it grows into a dandelion like aggregate,and the saponin acts as a template.Under the alkaline condition,it modifies and disperses,and the material tends to be regular and uniform.In order to fully study the role of sapindoside in the preparation of materials,the structure of sapindoside is calculated by the software of GaussView,and the optimal configuration and pair electrostatic distribution map are obtained.It is speculated that sapindoside could be used as template or modifier through electrostatic adsorption between organic matter and Ca2+.In this study,the principle of natural surfactant assisted preparation of HAP is studied from the perspective of quantum chemistry.It is not only of great significance to the development and research of HAP functional materials,but also expands the application of natural surfactants in the preparation of inorganic functional materials.

关 键 词：无患子皂苷 羟基磷灰石 量子化学 模板 修饰 

分 类 号：TB332[一般工业技术—材料科学与工程]