间充质干细胞微泡修复盆腔器官脱垂的展望:抗氧化应激  

Prospect of mesenchymal stem cell microvesicles repairing pelvic floor organ prolapse by antioxidant stress

作　　者：韩巧玲 平毅[2] HAN Qiaoling;PING Yi(Shanxi Medical University,Taiyuan 030000,Shanxi,China;Department of Obstetrics and Gynecology,the Second Hospital of Shanxi Medical University,Taiyuan 030000,Shanxi,China)

机构地区：[1]山西医科大学,山西太原030000 [2]山西医科大学第二医院妇产科,山西太原030000

出　　处：《中国临床药理学与治疗学》2021年第5期594-600,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：山西省自然科学基金(201901D111366)。

摘　　要：盆腔器官脱垂(POP)是中老年妇女中常见的因盆底筋膜和韧带松弛而导致的一类妇科疾病。大量研究表明,氧化应激(OS)是POP的核心机制之一。间充质干细胞(MSCs)作为再生医学中的研究热点,很多证据显示间充质干细胞可在心肌梗死、高氧性肺损伤等疾病中发挥抗氧化特性,从而减少炎症和氧化应激。此外,MSCs分泌的微泡(MVs)可通过蛋白质、mRNA、miRNA和脂质的转运,复制MSCs的功能,参与许多调节组织内稳态和疾病生理病理的生物学过程。本文就MSCs-MVs通过抗氧化应激在POP治疗中的潜在积极作用作一综述。Pelvic organ prolapse(POP)is a common gynecological disease caused by pelvic floor fascia and ligament relaxation in middle-aged and elderly women.A large number of studies have shown that oxidative stress(OS)is one of the core mechanisms of POP.Mesenchymal stem cells(MSCs)are a research hotspot in regenerative medicine.Many evidences show that MSCs can play antioxidant properties in myocardial infarction,hyperoxic lung injury and other diseases,thus reducing inflammation and oxidative stress.In addition,microvesicles(MVs)derived from MSCs secreted can replicate the functions of MSCs through protein,mRNA,miRNA and lipid transport,and participate in many biological processes regulating tissue homeostasis and disease physiology and pathology.This article reviews the potential positive effects of MSCs-MVs in the treatment of POP through antioxidant stress.

关 键 词：间充质干细胞 微泡 氧化应激 盆腔器官脱垂 

分 类 号：R271.23[医药卫生—中医妇科学]