嗜酸性粒细胞增多性皮炎16例回顾性分析  

Retrospective analysis of 16 cases of hypereosinophilic dermatitis

作　　者：张文 钱微露 熊健霞 蔡涛[2] ZHANG Wen;QIAN Weilu;XIONG Jianxia;CAI Tao(Chengdu Eighth People's Hospital,Chengdu 610017,China;The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]成都市第八人民医院,四川成都610017 [2]重庆医科大学附属第一医院,重庆400016

出　　处：《皮肤性病诊疗学杂志》2021年第2期117-121,共5页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：目的:探讨嗜酸性粒细胞增多性皮炎(HED)的临床特点、治疗方案及后期转归情况,为临床诊断和治疗提供参考。方法:对2014—2019年16例HED住院患者临床资料及实验室检查进行回顾性分析。结果:16例患者中,男女发病比为7∶1,皮疹主要表现为红斑、丘疹(约70%),多全身泛发,伴有明显瘙痒。误诊10例(62.50%)。糖皮质激素治疗敏感,雷公藤、沙利度胺、复方甘草酸苷及PUVA光疗对该病有不同程度缓解作用。结论:HED好发于男性,容易被误诊、漏诊。中小剂量糖皮质激素单用或联合免疫抑制剂治疗为当前最确切有效的治疗方案,部分有激素使用禁忌者可考虑予以复方甘草制剂或甲氨蝶呤、环孢素治疗。Objective:To explore the clinical features,treatment options and later outcomes of hypereosinophilic dermatitis(HED).Methods:A retrospective clinical data was analyzed for 16 HED inpatients from 2014 to 2019.Results:The ratio of male to female was 7∶1.The rash was mainly manifested as generalized itchy erythema and papules(about 70%).Among the 16 patients,10 patients(62.50%)were misdiagnosed.Treatment with glucocorticoids was effective.Tripterygium wilfordii,thalidomide,compound glycyrrhizin and PUVA phototherapy could alleviate clinical symptoms.Conclusions:HED tends to occur in male patients.Misdiagnosis and missed diagnosis of this disease are not uncommon.Low and medium-dose glucocorticoids alone or in combination with immunosuppressive agents are effective to treat patients with HED.Compound licorice preparations or methotrexate and cyclosporine can be considered for HED patients with contraindications of glucocorticoids or poor response to glucocorticoids.

关 键 词：嗜酸性粒细胞增多性皮炎 嗜酸性粒细胞 糖皮质激素 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]