Quantum model for understanding protein misfolding behavior——phase diagram and manual intervention  

作　　者：Wen-Wen Mao Li-Hua Lu You-Quan Li 

机构地区：[1]Zhejiang Province Key Laboratory of Quantum Technology&Device and Department of Physics,Zhejiang University,Hangzhou 310027,China [2]Collaberative Innovation Center of Advanced Microstructures,Nanjing University,Nanjing 210008,China

出　　处：《Science China(Physics,Mechanics & Astronomy)》2021年第6期10-16,共7页中国科学：物理学、力学、天文学（英文版）

基　　金：supported by the National Key Research and Development Program of China(Grant No.2017YFA0304304);the National Natural Science Foundation of China(Grant No.11935012)。

摘　　要：The study of protein folding is fundamental and important in the multidisciplinary field because a diversity of diseases,like Alzheimer’s and Parkinson’s are relevant to protein misfolding.The current thermodynamic and geometric approaches only phenomenologically describe but do not provide a mechanistic understanding of the competition between correct folding and misfolding.Here we present a model to understand the misfolding behavior.Considering the influence of dissipative strength for all possible sequences and comparing the folding time toward different compact structures,we obtain a phase diagram of the dissipative quantum phase transition that enables us to model the behavior.We also investigate how a perturbation in the Hamiltonian affects the transition point,which motivates us to explore possible manual interventions.Our results indicate that the manual intervention may be effective for some specific sequence but not for everyone.This approach is expected to lay a foundation for further studies on manual intervention in protein misfolding.

关 键 词：quantum phase diagram quantum walk mean first-passage time protein folding 

分 类 号：O413[理学—理论物理]