小胶质细胞上α7nAChR/BDNF/TrkB信号通路与神经病理性疼痛的关系研究  

The relationship betweenα7nAChR/BDNF/TrkB on signaling pathway in microglia and neuropathic pain

作　　者：贾丹丹 黄诚[2,3] JIA Dan-dan;HUANG Cheng(Gannan Medical University;School of Basic Medicine of Gannan Medical University;Pain Medicine Research Institute,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院 [2]赣南医学院基础医学院 [3]赣南医学院疼痛医学研究所,江西赣州341000

出　　处：《赣南医学院学报》2021年第4期332-337,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(31160213);赣鄱英才555工程领军人才项目;江西省主要学科学术和技术带头人培养计划项目(20142BCBC22008)。

摘　　要：神经病理性疼痛(Neuropathic pain,NP)是由神经损伤引起的一种顽固性慢性疼痛,表现为自发性疼痛、疼痛过敏和疼痛超敏等,神经病理性疼痛现有的临床药物大多数都是对症治疗,治标不治本,总体疗效欠佳,如要达到理想的治疗效果,进一步探讨神经病理性疼痛的发生与发展机制和病理生理过程是必不可少的。近几年,小胶质细胞成为神经病理性疼痛的研究热点。因此,本文就小胶质细胞上α7nAChR/BDNF/TrkB信号通路对神经病理性疼痛的作用进行综述。Neuropathic pain(NP)is a kind of stubborn chronic pain caused by nerve injury,manifested as spontaneous pain,allodynia and hyperalgesia,etc.Most of the existing clinical drugs for neuropathic pain are symptomatic treatment,with no treatment for the symptoms and no treatment for the root causes,and the overall effect is poor.To achieve the desired treatment effect,further exploration of the occurrence and development mechanism of neuropathic pain and pathology,the process of management is essential.In recent years,microglia have become the focus of neuropathic pain research.In this article,the role ofα7nAChR/BDNF/TrkB signaling pathway on microglia in neuropathic pain is summarized.

关 键 词：神经病理性疼痛 小胶质细胞 α7nAChR BDNF/TrkB通路 

分 类 号：R338.3[医药卫生—人体生理学]