核因子-κB(NF-κB)与核因子E2相关因子2(Nrf2)信号通路交互对结直肠癌防治及中药研究的启示  

Nuclear factor κB(NF-κB) and nuclear factor E2-related factor 2(Nrf2) signaling pathway crosstalk and its implications for prevention and treatment of colorectal cancer and research of Chinese medicine

作　　者：罗欢 何兰[1] 何迎春 魏行云 江志超 LUO Huan;HE Lan;HE Ying-chun;WEI Xing-yun;JIANG Zhi-chao(Hunan University of Chinese Medicine,Changsha 410208,Hunan Province,China;Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine,Changsha 410208,Hunan Province,China;Hunan Provincial Ophthalmology and Otolaryngology Diseases Prevention and Treatment with Traditional Chinese Medicine and Visual Function Protection Engineering and Technological Research Center,Changsha 410208,Hunan Province,China;The Second People’s Hospital of Hunan Province,Changsha 410007,Hunan Province,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]中医药防治眼耳鼻咽喉疾病湖南省重点实验室,湖南长沙410208 [3]湖南省中医药防治眼耳鼻咽喉疾病与视功能保护工程技术研究中心,湖南长沙410208 [4]湖南省第二人民医院,湖南长沙410007

出　　处：《中国临床药理学杂志》2021年第10期1266-1271,1276,共7页The Chinese Journal of Clinical Pharmacology

基　　金：湖南省自然科学基金资助项目(2018JJ2219);湖南省中医药科研计划重点基金资助项目(201540)。

摘　　要：结直肠癌(CRC)是全球第三大常见恶性肿瘤,已严重威胁人类健康。尽管近年来在结直肠癌的治疗方面已经取得一定进展,但是迫切需要找到能够早期诊断和有效治疗患者的新靶标,故针对肿瘤前后微环境的分子作用机制和关键控点进行系统研究,是研究结直肠癌防治的重点。对核因子κB(NF-κB)和核因子E2相关因子2(Nrf2)信号通路转导与结直肠癌发生发展的关系,以及它们之间错综复杂的交互作用(Crosstalk)进行综述,以期进一步了解结直肠癌发生发展机制,最后归纳中医药以其为靶点防治结直肠癌的已有研究成果,为结直肠癌的中医药防治提供思路与方向,为相关药物研发与应用提供参考依据。Colorectal cancer is the third most common malignant tumor in the world and it has seriously threatened human health. Although some progress has been made in the treatment of colorectal cancer in recent years, there is an urgent need to find new targets for early diagnosis and effective treatment of patients. Systematic research on the molecular mechanism and key control points of the microenvironment before and after the tumor is the focus of research on the occurrence and development of colorectal cancer. In this paper, the relationship between nuclear factor κB(NF-κB) and nuclear factor E2-related factor 2(Nrf2) signaling pathways and the occurrence and development of colorectal cancer, as well as their intricate crosstalk are summarized, to further understand the mechanism of the occurrence and development of colorectal cancer, provide a certain theoretical basis for the prevention and treatment of colorectal cancer. Finally, we also summarized the existing research of NF-κB and Nrf2 pathway in Chinese medicine for the prevention and treatment of colorectal cancer, which provides ideas and directions for the prevention and treatment of colorectal cancer with Chinese medicine, and provides a reference for the development and application of related drugs.

关 键 词：结直肠癌 核因子-κB(NF-κB)信号通路 核因子E2相关因子2(Nrf2)信号通路 交互作用 中医药 

分 类 号：R979.1[医药卫生—药品]