棕色和米色脂肪在肥胖中的研究进展  

Research progress of brown and beige fat in obesity

作　　者：张雅晴 王红蕊 张宇[2] 王金娥 ZHANG Ya-Qing;WANG Hong-Rui;ZHANG Yu;WANG Jin-E(College of Medical Science,China Three Gorges University,Yichang 443002,China;State Key Laboratory of Cardiovascular Disease,Sino-German Laboratory for Molecular Medicine,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)

机构地区：[1]三峡大学医学院,宜昌443002 [2]中国医学科学院北京协和医学院国家心血管病中心阜外医院心血管疾病国家重点实验室,北京100037

出　　处：《生命科学》2021年第3期355-362,共8页Chinese Bulletin of Life Sciences

基　　金：心血管疾病国家重点实验室开放课题(2018-kf04)。

摘　　要：目前随着人们生活水平的不断改善,肥胖及其相关疾病的发生率越来越高。虽然体育锻炼能够增加一定的能量消耗,但并不足以引起负能量平衡和体重下降。棕色和米色脂肪细胞的激活可使耗能增加、体重减轻以及胰岛素敏感性增加。因此,越来越多的研究进一步聚焦这两种产热脂肪组织增加能量消耗的分子机制,希望找到治疗肥胖及其相关疾病的靶点。现系统综述两种产热脂肪组织的分类、发育谱系、产热特性和产热机制的异同点并提出现阶段存在的不足以及发展方向,以期为肥胖及相关疾病的治疗提供新思路。At present,with the continuous improvement of people’s living standards,the incidence of obesity and related diseases is getting higher and higher.Although physical exercise can increase energy consumption to some extent,it is not enough to cause negative energy balance and weight loss.Activation of brown and beige adipocytes can lead to increased energy consumption,weight loss and increased insulin sensitivity.Therefore,more and more studies have focused on the molecular mechanism of these two thermogenic adipose tissues to increase energy consumption,so as to find targets for the treatment of obesity and related diseases.This paper systematically reviews the similarities and differences of the classification,developmental pedigree,thermogenic characteristics and thermogenic mechanism of the two kinds of thermogenic adipose tissue,and puts forward the shortcomings and development direction at the present stage,in order to provide new ideas for the treatment of obesity and related diseases.

关 键 词：棕色脂肪细胞 米色脂肪细胞 线粒体解耦联蛋白1 肥胖 

分 类 号：Q591.4[生物学—生物化学] Q946.5