华蟾素的抗癌镇痛机理及临床应用  

Mechanisms and clinical research of cinobufagin in anticancer andanalgesic

作　　者：郭莉 王艺蓉 梅迪 高媛媛 孙同毅[1] GUO Li;WANG Yirong;MEI Di;GAO Yuanyuan;SUN Tongyi(Shandong Key Laboratory of Proteins and Peptides Pharmaceutical Engineering,Shandong Universities Key Laboratory of Biopharmaceuticals,School of Life Science and Technology,Weifang Medical University,Weifang 261053,China;School of Pharmacy,Weifang Medical University,Weifang 261053,China)

机构地区：[1]潍坊医学院生命科学与技术学院,山东省蛋白质与多肽药物工程实验室,山东省高校生物药物重点实验室,潍坊261053 [2]潍坊医学院药学院,潍坊261053

出　　处：《生命的化学》2021年第3期487-494,共8页Chemistry of Life

基　　金：国家自然科学基金项目(81673576);山东省高等学校青创科技支持计划(2019KJM003)。

摘　　要：华蟾素主要来源于中华大蟾蜍及其他蟾蜍科动物干皮。华蟾素因具有抗癌、镇痛等功效且副作用小而受到了广泛关注。本文对近五年来华蟾素抗癌活性机制以及临床研究的最新进展进行了总结及归纳,以期为华蟾素的进一步研究提供方法及机制参考,同时为华蟾素应用于更多临床适应症以及提高治疗安全性提供支撑。Cinobufagin is mainly extracted from the dry skin of Bufobufogargarizans or other toads.It has attracted wide attention owing to its anticancer and analgesic effects with low side effects.In this paper,the anticancer activity mechanisms and clinical research progresses of cinobufagin in China during the past five years were summarized in order to provide methods and mechanisms reference for the further study of cinobufagin.At the same time,it provides support for the application of cinobufagin in more clinical indications and the enhancement of its therapeutic safety.

关 键 词：华蟾素 抗癌 镇痛 

分 类 号：R285[医药卫生—中药学]