基于蛋白质基因组学发现的新编码序列在疾病中的研究进展  

Progress on novel coding sequences by proteogenomics in diseases research

作　　者：蒙书红 张瑶 徐平 MENG Shu-Hong;ZHANG Yao;XU Ping(College of Life Sciences,Hebei University,Baoding 071002,China;Research Unit of Proteomics&Research and Development of New Drug of Chinese Academy of Medical Sciences,State Key Laboratory of Proteomics,Beijing Proteome Research Center,National Center for Protein Sciences.Beijing,Institute of Lifeomics,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 102206,China)

机构地区：[1]河北大学生命科学学院,保定071002 [2]军事科学院军事医学研究院生命组学研究所,国家蛋白质科学中心·北京,北京蛋白质组研究中心,蛋白质组学国家重点实验室,中国医学科学院蛋白质组学与新药研发新技术创新单元,北京102206

出　　处：《生命科学》2021年第2期223-230,共8页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31901037);“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(2018ZX10302302001003)。

摘　　要：非编码序列在不同物种全基因组中占了很大的比例,在人类基因组中高达98%以上。近年来,越来越多的研究发现,新编码序列不仅参与调控发育、分化、增殖与凋亡等生命活动,而且在疾病的发生发展等过程中也扮演了重要的角色。现对基于蛋白质基因组学发现的新编码序列在疾病中的鉴定及应用进行综述,有望为疾病预测、分型、诊断、治疗、疗效判断及预后的新型生物标志物和潜在治疗靶点研究提供丰富源泉。Non-coding sequences account for a large proportion in whole genome of different species, especially in human genome which is up to 98%. In recent years, an increasing number of studies have shown that novel coding sequences not only participate in life activities, such as the regulation of development, differentiation, proliferation, and apoptosis, and so on, but also play a significant role in occurrence and development of diseases. This paper reviewed the discovery and application of novel coding sequences based on proteogenomics in various diseases, which will provide rich resources for researching novel biomarkers and potential therapeutic targets of disease prediction, classification, diagnosis, treatment, curative effect judgment and prognosis.

关 键 词：非编码序列 蛋白质基因组学 新编码序列 疾病 

分 类 号：Q503[生物学—生物化学] Q51