New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity  

作　　者：SHAO Si-Yuan LI Ruo-Fei SUN Hua LI Shuai 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China

出　　处：《Chinese Journal of Natural Medicines》2021年第5期376-384,共9页中国天然药物（英文版）

基　　金：CAMS Innovation Fund for Medicial Sciences(CIFMS-2019-I2M-1-005)。

摘　　要：Seven new triterpenoid saponins,including five ursane-type saponins,ilexchinenosides R–V(1–5),and two oleananetype saponins,ilexchinenosides W–X(6–7),with four known triterpenoid saponins(8–11)were isolated from the leaves of Ilex chinensis.Their structures were elucidated by comprehensive spectroscopic 1 D and 2 D NMR and HR-ESI-MS data.Their sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and derivatization.Compounds 1,2,4,9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol(APAP)-induced Hep G2 cell injury in vitro.

关 键 词：Ilex chinensis Ursane and oleanane Triterpenoid saponins Hepatoprotective activity 

分 类 号：R284[医药卫生—中药学]