Type B polycyclic polyprenylated acylphloroglucinols from the roots of Hypericum beanii  

作　　者：LI Wei-Xian XU Wen-Jun LUO Jun YANG Lei KONG Ling-Yi 

机构地区：[1]Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China

出　　处：《Chinese Journal of Natural Medicines》2021年第5期385-390,共6页中国天然药物（英文版）

基　　金：the National Natural Science Foundation of China(No.31900287);the Drug Innovation Major Project(2018ZX09711-001-007);the China Postdoctoral Science Foundation(2017M621889)。

摘　　要：Two new type B polycyclic polyprenylated acylphloroglucinols(PPAPs)(1 and 2)and a known biogenetic precursor hyperbeanol Q(3)were isolated from the root extract of Hypericum beanii,a medicinal plant widespread in southwest China.Their chemical structures were elucidated by 1 D/2 D NMR and HRESIMS data analysis,and absolute configurations were determined through detailed electric circular dichroism(ECD)analysis including ECD exciton chirality,Mo2(OAc)4-induced ECD,and ECD comparison.Of these compounds,hyperbeone A(1)is a typical[3.3.1]-type B PPAP with an unusual C-1 geranyl side chain,and hyperberin C(2)possesses a rare bicyclo[5.3.1]hendecane core.Taking compound 3 as a starting point,a plausible biosynthetic pathway to the bicyclic type B frameworks of 1 and 2 was proposed.

关 键 词：Polyprenylated acylphloroglucinol Hypericum beanii Hyperbeone A ECD 

分 类 号：R284[医药卫生—中药学]