人血丙种球蛋白联合糖皮质激素对难治性肺炎支原体肺炎患儿T淋巴细胞亚群和炎性指标水平的影响  

T cell subsets and inflammatory indicator levels in children with refractory mycoplasma pneumonia

作　　者：孙爽爽 SUN Shuangshuang(Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州大学附属儿童医院河南省儿童医院郑州儿童医院小儿普内科,河南郑州450000

出　　处：《中国民康医学》2021年第8期120-121,124,共3页Medical Journal of Chinese People’s Health

基　　金：河南省医学科技攻关计划(课题编号:LHGJ20190946)。

摘　　要：目的:观察人血丙种球蛋白联合糖皮质激素对难治性肺炎支原体肺炎(RMPP)患儿T淋巴细胞亚群和炎性指标水平的影响。方法:选取56例RMPP患儿为研究对象,按随机数字表法将其分为对照组和观察组各28例。两组均给予常规治疗,在此基础上对照组予以糖皮质激素治疗,观察组在对照组基础上联合人血丙种球蛋白治疗。比较两组治疗前后T淋巴细胞亚群水平、炎性指标水平和不良反应发生率。结果:治疗后,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组白细胞计数和C反应蛋白水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:人血丙种球蛋白联合糖皮质激素治疗RMPP患儿可改善T淋巴细胞亚群水平,降低炎性指标水平,效果优于单纯糖皮质激素治疗。Objective:To investigate effects of human gamma globulin combined with glucocorticoids on T cell subsets and inflammatory indicator levels in children with refractory mycoplasma pneumonia(RMPP).Methods:56 children with RMPP were selected as the research objects,and were divided into control group and observation group according to the random number table method,28 cases in each group.Both groups were given conventional treatment.On this basis,the control group was treated with glucocorticoids,while the observation group was treated with human gamma globulin on the basis of that of the control group.The levels of T cell subsets,the levels of inflammatory indicators and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)levels of the observation group were higher than those of the control group;the CD8^(+)level was lower than that of the control group;and the differences were statistically significant(P<0.05).After the treatment,the white blood cell count and C-reactive protein level of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Human gamma globulin combined with glucocorticoids in the treatment of the children with refractory mycoplasma pneumonia(RMPP)can improve the levels of T cell subsets and reduce the levels of inflammatory indicators.Moreover,it is superior to single glucocorticoid treatment.

关 键 词：难治性肺炎支原体肺炎 儿童 人血丙种球蛋白 糖皮质激素 T细胞亚群 炎性指标 不良反应 

分 类 号：R725.6[医药卫生—儿科]