非霍奇金淋巴瘤合并静脉血栓栓塞症患者相关因素分析  

Analysis on related factors in patients with non-Hodgkin lymphoma complicating venous thromboembolism

作　　者：徐燕霞 黄静 杨宇佳 张慧琪[1] XU Yanxia;HUANG Jing;YANG Yujia;ZHANG Huiqi(Department of Hematology,Huzhou Municipal First People′s Hospital,Huzhou,Zhejiang 313000,China)

机构地区：[1]浙江省湖州市第一人民医院血液科,313000

出　　处：《重庆医学》2021年第10期1684-1687,1692,共5页Chongqing medicine

基　　金：浙江省湖州市科技计划公益性应用研究项目(2017GYB04)。

摘　　要：目的探讨非霍奇金淋巴瘤(NHL)合并静脉血栓栓塞症(VTE)患者的临床特征及相关风险因素。方法选择2016年8月至2019年8月该院血液科收治的NHL患者140例,分析其临床特征及发生VTE的相关风险因素。结果140例NHL患者中出现VTE 18例(12.8%),经单因素分析,NHL患者的疾病分期、健康状况、血红蛋白(Hb)、D二聚体、合并糖尿病、手术或外伤病史与VTE发生有关,差异有统计学意义(P<0.05)。经logistic线性回归分析,疾病分期(Ⅲ~Ⅳ期,OR=7.548,95%CI:1.997~28.534),Hb<100 g/L(OR=4.747,95%CI:1.204~18.715),健康状况[美国东部肿瘤协作组(ECOG)评分大于或等于3分,OR=2.986,95%CI:1.490~8.046]是NHL患者发生VTE的影响因素。结论根据NHL患者的临床分期、健康状况及实验室指标等,临床上可早期评估NHL患者发生VTE的风险性,并可以予以适当的用药从而降低VTE的发生率。Objective To investigate the clinical features and related risk factors in the patients with non-Hodgkin lymphoma(NHL)complicating venous thromboembolism(VTE).Methods A total of 140 patients with NHL complicating VTE treated in hematology department of this hospital from August 2016 to August 2019 were selected.Their clinical features and VTE occurrence related risk factors were analyzed.Results Among 140 cases of NHL,18 cases(12.8%)appeared VTE.The univariate analysis revealed that the disease stage,healthy status,Hb,D-dimers,complicating diabetes,history of surgery or trauma were related with the VTE occurrence,and the differences were statistically significant(P<0.05).The Logistic linear regression analysis showed that the disease stage(Ann Arbor stageⅢ-Ⅳ,OR=7.548,95%CI:1.997-28.534),Hb<100 g/L(OR=4.747,95%CI:1.204-18.715),healthy status(ECOG score≥3 points,OR=2.986,95%CI:1.490-8.046)were the influencing factors for the occurrence of VTE.Conclusion Clinic can early evaluate the risk of VTE occurrence in the patients with NHL according to the clinical stage,healthy status and laboratory indicators,and can give proper medication to reduce the occurrence of VTE.

关 键 词：非霍奇金淋巴瘤 静脉血栓栓塞症 临床特征 风险因素 

分 类 号：R551.2[医药卫生—血液循环系统疾病]