5-羟色胺对卵母细胞成熟及胚胎早期发育影响的研究进展  

Research progress of 5-hydroxytryptamine onoocyte maturation and early embryo development

作　　者：韩宇 张蒙 段佳慧 张学明 李子义[2] 唐博 HAN Yu;ZHANG Meng;DUAN Jiahui;ZHANG Xueming;LI Ziyi;TANG Bo(College of Veterinary Medicine,Jilin University,Changchun 130062,China;State&Local Joint Engineering Laboratory for Animal Models of Human Diseases,Academy of Translational Medicine,the First Bethune Hospital,Jilin University,Changchun 130062,China)

机构地区：[1]吉林大学动物医学学院,吉林长春130062 [2]吉林大学第一医院转化医学研究院人类疾病动物模型国家地方联合工程实验室,吉林长春130062

出　　处：《中国兽医学报》2021年第4期827-833,共7页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金面上资助项目(31472093)。

摘　　要：5-羟色胺(5-HT)是一种神经递质,广泛分布在中枢神经系统及胃肠道中,在雌性动物生殖组织中也有分布,其受体可分为7个亚家族,不同的受体通过多种信号通路发挥作用,参与广泛的生理活动,在调控卵泡发育、卵母细胞成熟及早期胚胎发育中发挥着重要的作用。本研究总结了5-HT的合成及代谢过程,以及5-HT及其受体家族的组成结构及发挥作用的信号通路,并对其在卵母细胞成熟及胚胎发育过程的影响进行了详细介绍,为了解5-HT及其受体家族在雌性哺乳动物生殖中发挥的作用提供依据。5-hydroxytryptamine(5-HT),a neurotransmitter,is widely distributed in the central nervous system and gastrointestinal tract,as well as in the reproductive tissues of female animals.5-HT receptors include 7subfamilies,which play functional roles through various signaling pathways and participate in a wide range of physiological activities,such as follicular development,oocyte maturation and early embryonic development.This article summarizes the synthesis and metabolism of 5-HT,as well as the structure and signal pathways of 5-HT and its receptor family.In addition,the effects of 5-HT on oocyte maturation and embryonic development are described in detail,which will provide important insights into the role of 5-HT and its receptor family in mammalian female reproduction.

关 键 词：5-羟色胺 5-羟色胺受体 卵母细胞成熟 胚胎发育 

分 类 号：S852.1[农业科学—基础兽医学]