Ⅰ型和Ⅲ型干扰素抗病毒作用机制的研究进展  

Progress in research on antiviral mechanism of types Ⅰ and Ⅲ interferon

作　　者：金丽 苏强(综述)[1,2] 周建华 马忠仁(审校) JIN Li;SU Qiang;ZHOU Jian-hua;MA Zhong-ren(Center for Biomedical Research,Northwest Minzu University,Lanzhou 730030,Gansu Province,China)

机构地区：[1]西北民族大学生物医学研究中心,甘肃兰州730030 [2]西北民族大学生命科学与工程学院,甘肃兰州730030 [3]甘肃农业大学动物医学学院,甘肃兰州730070

出　　处：《中国生物制品学杂志》2021年第4期481-486,共6页Chinese Journal of Biologicals

基　　金：中央高校基本科研业务费(31920170158)。

摘　　要：干扰素(interferon,IFN)是一类重要的细胞因子,直接参与上皮细胞的抗病毒免疫反应,介导天然免疫应答诱导IFN刺激基因(interferon stimulated gene,ISG)的表达,从而使机体快速建立针对病毒侵染的天然免疫防线。目前认为Ⅰ型和Ⅲ型IFN在很多功能上重叠相似,均具有抗病毒、抗肿瘤增殖和免疫调节作用。同时,在很大程度上,介导的信号通路也很相似。但Ⅰ型IFN在病毒感染早期即发挥抗病毒作用并可发挥长期免疫功能,期间反应迅速且能够强烈诱导ISG的产生,而Ⅲ型IFN则相对迟缓,且诱导ISG的能力有限,主要在天然免疫反应的黏膜免疫中发挥重要作用。此外,相关基因的表达导致IFN系统在遗传进化上出现差异,反映了物种间的差异性。本文对Ⅰ型和Ⅲ型IFN在免疫调节以及抗病毒领域方面的研究进展作一综述,以期为今后IFN介导相关免疫的研究提供参考。Interferon(IFN)is an important antiviral cytokine which directly involves in the antiviral immune response of epithelium and mediates the induction of interferon stimulated gene(ISG) by innate natural immune response thus establishes the natural immune defense against virus infection rapidly. It is currently believed that types Ⅰ and Ⅲ IFN have redundant functions,such as antiviral,anti-tumor proliferation and immunomodulatory effects. Meanwhile,the signaling pathways mediated by the two types are similar to a large extent. Type Ⅰ interferon exerts antiviral effect in the early stage of viral infection as well as long-term immune function,which is rapid in response and strongly induces the production of ISGs. However,typeⅢ interferon is relatively slow in response and limit in induction of ISGs,which plays an important role primarily in mucosal immunity in innate immune response. In addition,gene expression results in the difference in evolution of IFN system,reflecting the diversity between species. In this paper,the progress in research on the roles of typesⅠand Ⅲ interferon in immunomodulation and antiviral fields in order to provide a reference for study on IFN-mediated immunity.

关 键 词：干扰素 天然免疫系统 干扰素刺激基因 信号转导 遗传 

分 类 号：K978.7[历史地理—人文地理学]