Effect of Qishen Yiqi dripping pills combined with trimetazidine on the treatment of chronic heart failure: A meta-analysis  

作　　者：Feng Xie Guang-Jing Duan Bin Wang Pei-Feng Wei Lin Chen Min Li 

机构地区：[1]Shaanxi University of Traditional Chinese Medicine,Xianyang 712046 Shaanxi

出　　处：《Journal of Hainan Medical University》2021年第9期47-51,共5页海南医学院学报（英文版）

基　　金：National natural science foundation(No.81303243);the project of education department of Shanxi province(No.20JC012);the postgraduate innovation project of Shanxi university of traditional Chinese medicine(No.2020-6);the innovation team of Shanxi university of traditional Chinese medicine(No,2019-QN02)。

摘　　要：Objective:To systematically evaluate the safety and effectiveness of Qishen Yiqi dripping pills combined with trimetazidine in the treatment of chronic heart failure.Methods:A total of four English and Chinese electronic databases were searched:CNKI,VIP,CBM,PUBMED.Cochrane bias risk tools were used to assess the methodological quality of qualified studies.Meta-analysis was conducted by Review Manager 5.3.A total of 9 articles were included,with a total sample size of 855 cases,443 cases in the observation group and 412 cases in the treatment group.Results:Qishen Yiqi dripping pills combined with trimetazidine in the treatment of chronic heart failure has a total effective rate(RR=1.22,95%CI[1.15-1.30];p<0.00001),LVEF(MD=6.03,95%CI[5.39,6.67],P<0.00001),BNP(MD=-101.87,95%CI[-109.90,-93.83],P<0.00001),E/A(MD=-4.32,95%CI[-5.70,-2.93],P<0.00001),SYP(MD=-10.32,95%CI[-13.32,-7.32],P<0.00001),LVESD(MD=-5.50,95%CI[-6.03,-4.96],P<0.00001),6-MWT(MD=110.13,95%CI[96.89,123.36],P<0.00001)Adverse reactions occurred less frequently and did not affect treatment.Conclusion:This study shows that QYDP combined with TMZ can improve various indicators of CHF patients.However,due to the small sample size and the generally low quality of research,a more rigorous and reasonably designed RCT is needed to confirm these findings.

关 键 词：Qishen Yiqi dripping pills TRIMETAZIDINE Chronic heart failure META-ANALYSIS 

分 类 号：R54[医药卫生—心血管疾病]