氧化应激相关酶在心血管疾病中的研究进展  

Oxidative stress-related enzymes in cardiovascular diseases:research progress

作　　者：原野 王国坤[1] YUAN Ye;WANG Guo-kun(Department of Cardiovascular Surgery,Changhai Hospital,Naval Medical University(Second Military Medical University),Shanghai 200433,China)

机构地区：[1]海军军医大学(第二军医大学)长海医院心血管外科,上海200433

出　　处：《第二军医大学学报》2021年第5期538-542,共5页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81470592,81770477).

摘　　要：活性氧(ROS)持续产生氧化应激的过程与心血管疾病的发病有关。心血管系统中ROS的主要来源是还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶(NOX)、解偶联的内皮型一氧化氮合酶、线粒体和黄嘌呤氧化酶。本文就这些氧化酶之间的相互关系在心血管疾病中的作用进行综述,重点论述不同心血管疾病中被激活的NOX特定亚型的核心作用。理解这些机制有助于开发针对氧化应激相关酶系统及其之间相互作用的新型药物,有效预防和治疗心血管疾病。The continuous production of oxidative stress by reactive oxygen species(ROS)is related to the pathogenesis of cardiovascular diseases.The major enzymatic sources of ROS in the cardiovascular system are reduced nicotinamide adenine dinucleotide phosphate oxidase(NOX),uncoupled endothelial nitric oxide synthase,mitochondria,and xanthine oxidases.This article reviews the role of the relationship between these oxidases in cardiovascular diseases,focusing on the core role of specific subtypes of NOX that are activated in different cardiovascular diseases.An improved understanding of these mechanisms can facilitate the development of novel therapeutic agents targeting these oxidase stress-related enzyme systems and their interactions,which will be effective in the prevention and treatment of cardiovascular diseases.

关 键 词：活性氧 氧化性应激 氧化还原酶类 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]