HBV阳性孕妇开展Pre-S1与凝血指标检测的意义  

Significance of Pre-S1 and blood coagulation index detection in HBV positive pregnant women

作　　者：董文成 DONG Wen-cheng(Obstetrics and Gynecology Hospital Affiliated to Medical College of Zhejiang University,Hangzhou 310006,China)

机构地区：[1]浙江大学医学院附属妇产科医院,310006

出　　处：《中国现代药物应用》2021年第10期54-56,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析乙型肝炎病毒(HBV)阳性孕妇开展前S1抗原(Pre-S1)与凝血指标检测的重要意义。方法选取398例HBV阳性孕妇作为阳性组,400例HBV阴性孕妇作为阴性组。采集两组研究对象的空腹外周血标本,检测Pre-S1和凝血指标。比较两组孕妇的PreS1阳性率、凝血指标凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT),并分析乙型肝炎病毒的脱氧核糖核酸(HBV-DNA)与PreS1、凝血因子的相关性。结果阳性组孕妇的PT、APTT、TT长于阴性组,FIB高于阴性组,差异具有统计学意义(P<0.05)。阳性组孕妇PreS1阳性率为73.4%,高于阴性组的26.5%,差异具有统计学意义(P<0.05)。HBV-DNA水平与PreS1、PT、APTT、TT呈正相关(r=0.41、0.36、0.74、0.37,P<0.05),与FIB水平呈负相关(r=-0.15,P<0.05)。结论HBV阳性孕妇接受PreS1和凝血指标检查,可以帮助制定预防异常出血策略,减少孕妇产后大出血等不良反应,提高治疗有效率。Objective To analyze the significance of Pre-S1 antigen and blood coagulation index detection in hepatitis B virus(HBV)positive pregnant women.Methods There were 398 HBV-positive pregnant women selected as the positive group,and 400 HBV-negative pregnant women as the negative group.The fasting peripheral blood samples of the two groups were collected to detect Pre-S1 and coagulation indicators.The PreS1 positive rate,and coagulation indexes[prothrombin time(PT),thrombin time(TT),fibrinogen(FIB),activated partial thromboplastin time(APTT)]were compared between the two groups.The correlation between hepatitis B virus deoxyribonucleic acid(HBV-DNA)and PreS1 and blood coagulation factors was analyzed.Results The PT,APTT and TT of positive group were longer than those of negative group,and FIB was higher than that of negative group.All the difference was statistically significant(P<0.05).The PreS1 positive rate of positive group was 73.4%,which was higher than 26.5%of negative group,and the difference was statistically significant(P<0.05).HBV-DNA level was positively correlated with PreS1,PT,APTT,TT(r=0.41,0.36,0.74,0.37,P<0.05),and negatively correlated with FIB level(r=-0.15,P<0.05).Conclusion Pre-S1 antigen and coagulation index detection in HBV positive pregnant women can help to develop strategies to prevent abnormal bleeding,reduce adverse reactions such as postpartum massive bleeding,and improve the treatment efficiency.

关 键 词：乙型肝炎病毒阳性 孕妇 前S1抗原 凝血指标检测 

分 类 号：R512.62[医药卫生—内科学]