外周血内病毒指标及PLT水平对乙肝肝硬化患者病情和预后的影响  

Impacts of virus index and PLT level in peripheral blood on the condition and prognosis of patients with hepatitis B cirrhosis

作　　者：程辉[1] CHENG Hui(Department of Hepatology,Xuzhou Infectious Disease Hospital,Xuzhou 221000,China)

机构地区：[1]江苏省徐州市传染病医院肝病科,江苏徐州221000

出　　处：《中国现代医生》2021年第12期108-111,共4页China Modern Doctor

摘　　要：目的评价病毒指标及PLT水平对乙肝肝硬化患者病情和预后的影响。方法选择2016年4月至2020年5月我院收治的乙肝肝硬化患者110例,根据Chid-Pugh肝功能分级标准进行分组,比较各组Child-Pugh评分、病毒指标及PLT水平;根据患者是否发生并发症进行分组,比较两组患者外周血内并发症指标、PLT水平,采用二元Logistic回归分析筛选并发症发生的独立影响因素。结果随着肝功能分级的升高,Child-Pugh评分及HBcAb滴度逐渐增加,而HBsAg滴度Log值、HBcAb-IgM滴度及PLT计数逐渐降低,差异有统计学意义(P<0.05);有并发症组和无并发症HBsAg滴度Log值、HBcAb滴度及PLT计数相比差异有统计学意义(P<0.05);肝功能Child-Pugh评分与HBsAg滴度Log值、HBcAb-IgM滴度及PLT计数呈负相关(P<0.05),与HBcAb滴度呈正相关(P<0.05)。外周血HBsAg滴度Log值、HBcAb滴度及PLT计数是肝硬化患者并发症发生的独立影响因素(P<0.05)。结论乙肝肝硬化患者随肝功能分级的增加,患者外周血HBcAb滴度逐渐增加,而HBsAg滴度Log值、HBcAb-IgM滴度及PLT计数逐渐降低,有并发症的肝硬化患者HBsAg滴度Log值、PLT计数水平较低,HBcAb滴度较高,多指标联合检测可用于评估乙肝肝硬化患者病情和预后。Objective To evaluate the impacts of virus index and PLT level on the condition and prognosis of patients with hepatitis B cirrhosis.Methods A total of 110 patients with hepatitis B cirrhosis admitted to our hospital from April 2016 to May 2020 were selected and divided into groups according to Chid-Pugh hepatic function grading standard.And the Child-Pugh score,virus index and PLT level of each group were compared.The patients were divided into groups according to whether complications occurred.The indexes of complications and PLT levels in peripheral blood were compared between the two groups of patients.The independent impacting factors of complications were screened by binary logistic regression analysis.Results With the increase of hepatic function grade,Child-Pugh score and HBcAb titer increased gradually,while HBsAg titer log value,HBcAb-IgM titer and PLT count decreased gradually,with statistically significant differences(P<0.05).There were statistically significant differences in HBsAg titer log value,HBcAb titer and PLT count between the complication group and the non-complication group(P<0.05).Child-Pugh score of hepatic function was negatively correlated with HBsAg titer log value,HBcAb-IgM titer and PLT count(P<0.05),while positively correlated with HBcAb titer(P<0.05).HBsAg titer log value,HBcAb titer and PLT count in peripheral blood were independent impacting factors of complications in patients with liver cirrhosis(P<0.05).Conclusion With the increase of hepatic function grade,the HBcAb titer in peripheral blood of patients with hepatitis B cirrhosis gradually increased,while the HBsAg titer log value,HBcAb-IgM titer and PLT count gradually decreased.The HBsAg titer log value and PLT count level were lower and HBcAb titer was higher in patients complicated with liver cirrhosis.Multi-index combined detection can be used to evaluate the condition and prognosis of patients with hepatitis B cirrhosis.

关 键 词：病毒学指标 PLT 乙肝肝硬化 预后 

分 类 号：R512.6[医药卫生—内科学]