丹参酮Ⅱ_(A)磺酸钠注射液联合胺碘酮治疗室性早搏的疗效观察  

Clinical observation on Sulfotanshinone Sodium Injection combined with amiodarone in treatment of ventricular premature beat

作　　者：宋雨 王涛 SONG Yu;WANG Tao(Department of Cardiology,Fuyang Cancer Hospital,Fuyang 236000,China)

机构地区：[1]阜阳市肿瘤医院心血管内科,安徽阜阳236000

出　　处：《药物评价研究》2021年第4期809-813,共5页Drug Evaluation Research

摘　　要：目的探讨丹参酮Ⅱ_(A)磺酸钠注射液联合胺碘酮治疗室性早搏的疗效。方法选取2018年7月—2020年3月阜阳市肿瘤医院收治的96例室性早搏患者作为研究对象,按照治疗方法将患者分为对照组和观察组,每组各48例。对照组患者口服盐酸胺碘酮片,0.2 g/次,3次/d。观察组在对照组的基础上静脉滴注丹参酮Ⅱ_(A)磺酸钠注射液,80 mg/次,1次/d。两组均连续治疗2周。观察两组患者的临床疗效,同时比较两组治疗前后的室性早搏次数、ST段下移时间、ST段压低距离、每搏输出量(SV)、心输出量(CO)、阻力指数(RI)。结果治疗后,观察组临床总有效率93.75%,显著高于对照组的79.17%,差异有统计学意义(P<0.05)。治疗后,两组的室性早搏次数、ST段下移时间、ST段压低距离均显著降低(P<0.05);观察组治疗后的室性早搏次数、ST段下移时间、ST段压低距离均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的SV、CO显著升高,RI显著降低(P<0.05);观察组治疗后的SV、CO高于对照组,RI低于对照组,差异有统计学意义(P<0.05)。结论丹参酮Ⅱ_(A)磺酸钠注射液联合胺碘酮可提高室性早搏的疗效,改善患者血流动力学,改善心电图的水平,安全性较好,具有良好的临床研究价值。Objective To investigate the effect of Sulfotanshinone Sodium Injection combined with amiodarone in treatment of patients with ventricular premature beats.Methods A total of 96 patients with ventricular premature beats admitted to Fuyang Cancer Hospital from July 2018 to March 2020 were selected as the research subjects.According to the treatment methods,the patients were divided into control group and observation group,with 48 patients in each group.Patients in the control group were po administered with Amiodarone Hydrochloride Tablets,0.2 g/time,three times daily.Patients in the observation group were iv administered with Sulfotanshinone Sodium Injection on the basis of control group,80 mg/time,once daily.Both groups were treated continuously for two weeks.Clinical efficacy of two groups was observed,and the frequency of premature ventricular beats,ST segment displacement time,ST segment depression distance,SV,CO,and RI before and after treatment were compared between two groups.Results After treatment,the total clinical effective rate of the observation group was 93.75%,which was significantly higher than 79.17% of the control group,the difference being statistically significant(P<0.05).After treatment,the frequency of premature ventricular beats,ST segment descending time,and ST segment depression distance were significantly decreased in both groups(P<0.05).The frequency of premature ventricular beats,ST segment downshift time and ST segment depression distance in the observation group were lower than those in the control group after treatment,with statistical significance(P<0.05).After treatment,SV and CO in two groups were significantly increased,while RI was significantly decreased(P<0.05).After treatment,SV and CO in the observation group were higher than those in the control group,while RI in the observation group was lower than those in the control group,with statistical significance(P<0.05).Conclusion Sulfotanshinone Sodium Injection combined with amiodarone can improve the therapeutic efficacy of ven

关 键 词：丹参酮Ⅱ_(A)磺酸钠注射液 胺碘酮 室性早搏 ST段下移时间 ST段压低距离 每搏输出量 心输出量 阻力指数 

分 类 号：R972[医药卫生—药品]