氧化苦参碱抗心律失常作用及其机制的研究进展  

Research advance on antiarrhythmic action and mechanism of oxymatrine

作　　者：张明发[1] 沈雅琴[1] ZHANG Mingfa;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.Ltd.,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《药物评价研究》2021年第4期900-908,共9页Drug Evaluation Research

摘　　要：氧化苦参碱对心脏具有正性肌力和负性频率作用,对心肌自律性:在低浓度时降低、高浓度时提高自律性。氧化苦参碱能显著降低变为慢反应细胞的心室肌的自律性。其正性肌力作用的机制系促进外钙内流,从而促进心肌细胞内的肌浆网钙大量释放所致。而负性自律性和负性频率产生的机制与阻滞钠离子通道有关。因此氧化苦参碱能防治心力衰竭、心肌缺血和各种化学品引起的心律失常。Matrine has positive inotropic action and negative chronotropic action,and in myocardial automaticity low concentration decreasing and high concentration increasing automaticity.Oxymatrine decreases myocardial automaticity of becoming slow response cells.The mechanisms of positive inotropic action is promoting extracellular calcium to flow into intracellular.thus promoting Ca2+release of sarcoplasmic reticulum in myocardium.The mechanism of negative automaticity and negative chronotropic action may relate to blocking Na+channel,oxymatrine can prevent and treat arrhythmia induced by heart failure,myocardial ischemia,and various chemicals.

关 键 词：氧化苦参碱 心律失常 心力衰竭 心肌缺血 

分 类 号：R285.5[医药卫生—中药学]