调节性T细胞糖代谢的研究进展  

Review of glucose metabolism in regulatory T cells(Tregs)

作　　者：徐睿 王芳[1] XU Rui;WANG Fang(Department of Laboratory Medicine&National Key Clinical Department of Laboratory Medicine,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院检验学部,江苏南京210029

出　　处：《细胞与分子免疫学杂志》2021年第4期378-382,共5页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金(81772779);江苏省实验诊断学重点实验室基金(XK201114)。

摘　　要：过去普遍认为调节性T细胞(Treg)多通过葡萄糖和脂肪酸的氧化磷酸化途径进行能量代谢。然而,最近有研究表明Treg的实际代谢方案要比想象的灵活得多。在某些情况下如肿瘤微环境中,Treg可能相对于效应T细胞有更活跃的糖酵解活动。Treg的不同代谢途径之间可能存在一定的"分工"以实现不同的功能,其调节主要受哺乳动物雷帕霉素靶蛋白(mTOR)和缺氧诱导因子1α(HIF-1α)的调控。了解Treg糖代谢的表型、调节机制和动态变化,将为自身免疫性疾病、肿瘤等免疫相关疾病的防治提供有效的分子靶点和潜在的临床治疗方法和工具。In the past,regulatory T cells(Tregs)were generally believed to be involved in energy metabolism through oxidative phosphorylation of glucose and fatty acids.However,recent studies have shown that Tregs’actual metabolic regimen is much more flexible than previously thought.In some cases,such as in the tumor microenvironment,the glycolysis of Tregs may be more active than that of effector T cells.There may be some"division of labor"between different metabolic pathways of Tregs,which are mainly regulated by mTOR and hypoxia inducible factor-1α(HIF-1α).Further understanding of the phenotype,regulatory mechanisms and dynamic changes of Tregs glucose metabolism may provide effective molecular targets and potential clinical treatment methods for the prevention and treatment of autoimmune diseases,tumor and other immune-related diseases.

关 键 词：调节性T细胞(Treg) 糖代谢 调控机制 综述 

分 类 号：R392.12[医药卫生—免疫学] R392.11[医药卫生—基础医学]