冠状动脉粥样硬化性心脏病患者血清Wnt-1、DKK-1及红细胞分布宽度水平的改变及其意义  

Changes and significance of serum Wnt-1,DKK-1 and red blood cell distribution width levels in patients with coronary atherosclerotic heart disease

作　　者：刘彤彤 李元民 LIU Tongtong;LI Yuanmin(Shandong First Medical University,Taian 271021,Shandong Province,China;Department of Cardiology,The Second Affiliated Hospital of Shandong First Medical University,Taian 271000,Shandong Province,China)

机构地区：[1]山东第一医科大学,山东泰安271021 [2]山东第一医科大学第二附属医院心内科,山东泰安271000

出　　处：《世界临床药物》2021年第4期253-257,共5页World Clinical Drug

基　　金：山东省自然科学基金(ZR2017MH097)。

摘　　要：近来研究显示,早期冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease,CHD)患者具有Wnt信号通路缺陷特征,而Wnt通路由包括DKK在内的多种拮抗剂家族所调控,反映在生化指标上表现为血清Wnt-1水平降低,DKK水平升高。红细胞分布宽度(red blood cell distribution width,RDW)是反映红细胞大小是否均一的指标,既往常被用于诊断血液病,近来研究发现红细胞也参与炎症反应及动脉粥样硬化的过程,证明血清RDW水平与CHD也有一定的相关性,本文对CHD患者外周血中Wnt-1、DKK-1及RDW水平的关系作一综述。Recent studies have found that patients with early-onset coronary atherosclerotic heart disease (CHD) have the characteristics of Wnt signaling pathway defects,and Wnt pathway is regulated by a variety of antagonists including DKK.Therefore,the level of serum Wnt-1 in patients with coronary heart disease is decreased,while the level of DKK is increased.Other studies have found that red blood cell distribution width (RDW),as an indicator to reflect whether the size of red blood cells is uniform,also participates in the process of inflammation and atherosclerosis,which proves that there is a certain correlation between serum RDW level and CHD.This article reviewed the relationship between Wnt-1,DKK-1 and RDW levels in peripheral blood of CHD.

关 键 词：WNT-1 DKK-1 红细胞分布宽度 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]