水蛭素的药理作用及临床应用研究进展  

Research Progress on Pharmacological Action and Clinical Application of Hirudin

作　　者：徐明杰 赵迪 李龙宇[1,2,3] 伍一炜 徐暾海 刘铜华[2,3] XU Ming-jie;ZHAO Di;LI Long-yu;WU Yi-wei;XU Tun-hai;LIU Tong-hua(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China;Beijing Key Laboratory of Health-cultivation,Beijing University of Chinese Medicine,Beijing 100029,China;Health-cultivation Laboratory,Ministry of Education,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学中药学院,北京100029 [2]北京中医药大学中医养生学北京市重点实验室,北京100029 [3]北京中医药大学中医养生学教育部重点实验室,北京100029

出　　处：《中国现代中药》2021年第4期747-754,共8页Modern Chinese Medicine

基　　金：国家国际科技合作项目(2010DFB33260)。

摘　　要：水蛭素(hirudin)为特异性凝血酶抑制剂,根据其来源可分为天然水蛭素和重组水蛭素两类。水蛭素具有抗凝、抗血栓、抗纤维化、抗细胞凋亡、舒血管和提高随意皮瓣成活率等多种药理作用,对于血管瘤、肝癌、动脉粥样硬化症、肾病综合征、高尿酸血症、输卵管炎性阻塞和白内障等疾病均具有显著的治疗作用。对近年来水蛭素的相关研究进行综述,为其进一步研发提供参考。Hirudin is the strongest specific thrombin inhibitor discovered to date.A large number of basic experimental and clinical studies have confirmed that hirudin has a variety of pharmacological effects,such as anticoagulation,antithrombotic,anti-fibrosis,anti-apoptosis,vascularization and improvement of survival rate of free skin flap.At the same time,it has a significant therapeutic effect on hemangioma,liver cancer,atherosclerosis,nephrotic syndrome,hyperuricemia,salpingitis obstruction and cataract and so on.In this paper,the research on hirudin in recent years is analyzed and summarized to provide reference for its further development.

关 键 词：水蛭素 重组水蛭素 药理作用 临床应用 不良反应 

分 类 号：R285[医药卫生—中药学]