幽门螺杆菌感染与慢性荨麻疹相关性研究  

Study on the relationship between Helicobacter pylori infection and chronic urticaria

作　　者：王迎伟[1] 王利平[2] 龙颖 莫双阳[1] 秦和平[1] WANG Yingwei;WANG Liping;LONG Ying;MO Shuangyang;QIN Heping(Department of Gastroenterology,the Liuzhou General Hospital,Liuzhou,Guangxi,545000,China;Department of Dermatology,the Liuzhou General Hospital,Liuzhou,Guangxi,545000,China)

机构地区：[1]柳州市人民医院消化科,广西柳州545000 [2]柳州市人民医院皮肤科,广西柳州545000

出　　处：《当代医学》2021年第16期97-99,共3页Contemporary Medicine

摘　　要：目的探究幽门螺杆菌感染(Helicobacter pylori,Hp)与慢性荨麻疹(chronic urticaria,CU)相关性,为CU患者提供更有效的诊疗策略。方法选取2015年6月至2017年12月在柳州市人民医院皮肤科门诊确诊慢性荨麻疹患者290例作为实验组,另选取本院健康体检者310名作为对照组。应用^(14)C呼气试验检测实验组和对照组Hp感染情况,将慢性荨麻疹Hp阳性患者113例分为A(n=55)、B(n=58)两组,A组行常规治疗荨麻疹方案,B组在A组基础上联合抗Hp标准四联疗法治疗,比较实验组和对照组Hp检测结果,比较A组和B组临床疗效。结果实验组阳性率为39.0%,明显高于对照组的29.7%,差异有统计学意义(P<0.05);B组治疗总有效率为67.2%,高于A组的47.3%,差异具有统计学意义(P<0.05)。结论Hp感染与慢性荨麻疹有一定相关性,针对Hp的检测和治疗可为慢性荨麻疹患者的临床诊疗提供重要参考。Objetive To study the relationship between Helicobacter pylori(Hp)infection and chronic urticaria(CU),provide more effective diagnosis and treatment strategy for patients with CU.Methods 290 patients with chronic urticaria diagnosed in the Dermatology of Liuzhou People's Hospital from June 2015 to December 2017 were selected as the experimental group,and 310 healthy subjects in our hospital were selected as the control group.The ^(14)C breath test was used to detect Hp infection in the experimental group and the control group.113 patients with Hp-positive chronic urticaria were divided into two groups A(n=55)and B(n=58).Group A received conventional treatment for urticaria.Group B was treated with standard anti-Hp quadruple therapy on the basis of Group A,compare the Hp test results of the experimental group and the control group,compare the clinical efficacy of group A and group B.Results The positive rate in the experimental group was 39.0%,which was significantly higher than 29.7%in the control group,and the difference was statistically significant(P<0.05);the total effective rate of treatment in group B was 67.2%,which was higher than 47.3%in group A,and the difference was statistically significant(P<0.05).Conclusion Hp infection is associated with chronic urticaria.The detection and treatment of Hp can provide important reference for clinical diagnosis and treatment of chronic urticaria.

关 键 词：幽门螺杆菌 慢性荨麻疹 ^(14)C呼气试验 流行率 

分 类 号：R758.24[医药卫生—皮肤病学与性病学] R573[医药卫生—临床医学]