阿司匹林联用拉贝洛尔对早期妊娠期高血压疾病患者血压水平及妊娠结局的影响  

Eff ect of aspirin combined with labelolol on blood pressure and pregnancy outcome in patients with preeclampsia

作　　者：林楠[1] 石丽[1] 林晓岚[1] 钟宛杞 Lin Nan;Shi Li;Lin Xiaolan;Zhong wanqi(Department of Obstetrics and Gynecology,Zhongshan Xiaolan People's Hospital,Zhongshan 528415,China)

机构地区：[1]中山市小榄人民医院妇产科,广东中山528415

出　　处：《实用妇科内分泌电子杂志》2021年第1期52-55,共4页Electronic Journal of Practical Gynecological Endocrinology

基　　金：中山市科技局计划项目(编号2020B1052)。

摘　　要：目的探讨早期妊娠期高血压疾病采用阿司匹林联用拉贝洛尔治疗对其血压水平及妊娠结局的影响。方法选取106例早期妊娠期高血压疾病患者,采用双盲法分成研究组与对照组,每组53例。对照组采用拉贝洛尔注射液治疗,研究组在对照组基础上联合阿司匹林肠溶片治疗,比较两组患者治疗前后血压水平、凝血指标及不良妊娠结局。结果治疗前,两组患者舒张压、收缩压水平比较,差异无统计学意义(P>0.05);治疗后,研究组舒张压、收缩压水平均低于治疗前及对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者纤维蛋白原(FIB)、凝血酶原时间(PT)及活化部分凝血活酶时间(APTT)水平比较,差异无统计学意义(P>0.05);治疗后,研究组FIB水平显著低于治疗前及对照组,PT及APTT水平显著高于治疗前及对照组,差异具有统计学意义(P<0.05)。研究组不良妊娠结局发生率为7.55%,显著低于对照组的22.64%,差异具有统计学意义(P<0.05)。结论早期妊娠期高血压疾病患者采用阿司匹林联合拉贝洛尔治疗不仅能有效控制其血压,可改善其凝血功能,使其获得良好的妊娠结局。Objective To investigate the eff ect of pregnancy induced hypertension syndrome(PESH)treated with aspirin and labelolol on blood pressure and pregnancy outcome.Methods A total of 106 patients with preeclampsia were divided into study group and control group by double blind method,with 53 cases in each group.The control group was treated with Labelol injection,and the research group was treated with Aspirin Enteric-coated Tablets on the basis of the control group.The blood pressure levels,blood coagulation indexes and adverse pregnancy outcomes of the two groups were compared before and after treatment.Results Before treatment,there was no statistical significance in diastolic blood pressure and systolic blood pressure between 2 groups(P>0.05).After treatment,the levels of diastolic blood pressure and systolic blood pressure in the study group were lower than those before treatment and those in the control group,with statistical signifi cance(P<0.05).Before treatment,there were no signifi cant differences in the levels of fibrinogen(FIB),prothrombin time(PT)and activated partial thromboplastin time(APTT)between 2 groups(P>0.05).After treatment,the FIB level in the study group was significantly lower than before treatment and control group,and the PT and APTT levels were signifi cantly higher than before treatment and control group,with statistical signifi cance(P<0.05).The incidence of adverse pregnancy outcomes in the study group was 7.55%,which was signifi cantly lower than that in the control group(22.64%),and the diff erence was statistically signifi cant(P<0.05).Conclusion Preeclampsia patients with aspirin combined with labelolol can not only eff ectively control their blood pressure,can improve their coagulation function,so that they get a good pregnancy outcome.

关 键 词：妊娠期高血压疾病 阿司匹林 拉贝洛尔 血压水平 妊娠结局 

分 类 号：R714.246[医药卫生—妇产科学]