黄体酮注射液治疗黄体功能不全所致先兆流产的不良反应发生率评价  

Evaluation of adverse reaction rate of progesterone injection in treatment of threatened abortion caused by luteal insuffi ciency

作　　者：贾妮 欧燕兰 Ja Ni;Ou Yanlan(Department of Obstetrics and Gynecology,the Second People's Hospital of Nansha District,Guangzhou 511455,China)

机构地区：[1]广州市南沙区第二人民医院妇产科,广东广州511455

出　　处：《实用妇科内分泌电子杂志》2021年第1期59-61,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的评价黄体酮治疗黄体功能不全所致先兆流产的安全性。方法选取50例黄体功能不全所致先兆流产患者,采用随机数字表法将患者分为参照组与研究组,每组25例。参照组采用常规治疗,研究组在参照组基础上联合黄体酮治疗,比较两组患者激素指标、不良反应发生情况及临床疗效。结果研究组患者黄体酮、雌二醇、人绒毛膜促性腺激素水平(HCG)指标均高于参照组,差异具有统计学意义(P<0.05)。研究组患者不良反应发生率为12.00%,明显低于参照组的44.00%,差异具有统计学意义(P<0.05)。研究组患者总有效率为92.00%,显著高于参照组的60.00%,差异有统计学意义(P<0.05)。结论黄体酮治疗黄体功能不全所致先兆流产有助于改善并提高患者各项激素指标,减少不良反应发生率,有效提高临床疗效,维持正常妊娠,值得临床推广与应用。Objective To evaluate the safety of progesterone in the treatment of threatened abortion due to luteal insufficiency.Methods 50 patients with threatened abortion caused by luteal insufficiency were selected and divided into reference group and study group by random number table method,with 25 cases in each group.The reference group was treated with conventional treatment,while the research group was treated with progesterone on the basis of the reference group.Hormone indexes,the incidence of adverse reactions and clinical effi cacy were compared between the two groups.Results The levels of progesterone,estradiol and human chorionic gonadotropin(HCG)in the study group were higher than those in the control group,and the diff erence was statistically signifi cant(P<0.05).The incidence of adverse reactions in the study group was 12.00%,signifi cantly lower than that in the control group(44.00%),and the diff erence was statistically signifi cant(P<0.05).The total eff ective rate of the study group was 92.00%,signifi cantly higher than that of the control group(60.00%),the diff erence was statistically signifi cant(P<0.05).Conclusion Progesterone in the treatment of threatened abortion caused by luteal insuffi ciency is helpful to improve and improve the hormone indexes of patients,reduce the incidence of adverse reactions,eff ectively improve clinical effi cacy,maintain normal pregnancy,and is worthy of clinical promotion and application.

关 键 词：先兆流产 黄体功能不全 黄体酮 不良反应 

分 类 号：R714.21[医药卫生—妇产科学]