升阳益胃汤加减治疗脾肺气虚型慢性荨麻疹的临床观察  

Clinical Observation of Modified Shengyang Yiwei Decoction in Treating Chronic Urticaria with Syndrome of Spleen-Lung Qi Deficiency

作　　者：刘星显 程旭阳 宋文英[2] LIU Xing-Xian;CHENG Xu-Yang;SONG Wen-Ying(Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《广州中医药大学学报》2021年第6期1154-1158,共5页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察升阳益胃汤加减治疗脾肺气虚型慢性荨麻疹的临床效果。【方法】将80例脾肺气虚型慢性荨麻疹患者随机分为观察组和对照组,每组各40例。对照组给予口服盐酸西替利嗪治疗,观察组在对照组的基础上给予升阳益胃汤加减治疗,疗程为4周。观察2组患者治疗前后症状、体征评分的变化情况,评价2种治疗方案的临床疗效、复发情况和安全性。【结果】(1)治疗4周后,观察组的愈显率和总有效率分别为72.5%(29/40)和87.5%(35/40),对照组分别为32.5%(13/40)和52.5%(21/40)。组间比较,观察组的愈显率和总有效率均明显高于对照组,差异均有统计学意义(P<0.05)。(2)治疗后,2组患者的风团数量、风团大小、瘙痒程度、每周发作次数等症状体征评分均较治疗前明显降低(P<0.05),且观察组的降低作用均明显优于对照组,差异均有统计学意义(P<0.05)。(3)治疗结束1个月后,观察组的复发率为10.34%(3/29),明显低于对照组的53.85%(7/13),差异有统计学意义(P<0.05)。(4)在治疗过程中及治疗后1个月的电话回访中,2组患者均未发生明显的不良反应。【结论】升阳益胃汤加减治疗脾肺气虚型慢性荨麻疹疗效显著,复发率低,且安全性高。Objective To observe the clinical effect of modified Shengyang Yiwei Decoction for the treatment of chronic urticaria with the syndrome of spleen-lung qi deficiency. Methods Eighty cases of chronic urticaria with the syndrome of spleen-lung qi deficiency were randomly divided into observation group and control group,40 cases in each group. The control group was treated with Cetirizine Hydrochloride Tablets orally, and the observation group was given oral use of modified Shengyang Yiwei Decoction combined with Cetirizine Hydrochloride Tablets. The treatment for the two groups lasted for 4 weeks. Before and after treatment,the scores of the clinical symptoms and signs in the two groups were observed. After treatment, the clinical efficacy,recurrence rate and clinical safety of the two treatment regimens were evaluated. Results(1)After 4 weeks of treatment,the cured and markedly effective rate and the total effective rate of the observation group were 72.5%(29/40)and 87.5%(35/40)respectively,and those of the control group were 32.5%(13/40)and 52.5%(21/40)respectively. The intergroup comparison showed that the cured and markedly effective rate and the total effective rate of the observation group were significantly higher than those of the control group,and the differences being statistically significant(P < 0.05).(2)After treatment,the scores of symptoms and signs such as wheal count,wheal size, itching degree, and weekly attack frequency in the patients of both groups were significantly decreased in comparison with those before treatment(P < 0.05),and the effect on decreasing the scores in the observation group was superior to that in the control group,the difference being statistically significant(P < 0.05).(3)One month after the completion of the treatment,the recurrence rate of the observation group was 10.34%(3/29),and was much lower than that of the control group(7/13,53.85%),the difference being statistically significant(P < 0.05).(4)During the treatment and one month after treatment,the results of follow-up

关 键 词：升阳益胃汤 慢性荨麻疹 脾肺气虚型 临床研究 

分 类 号：R275.9[医药卫生—中西医结合]