神道八阵穴隔药灸联合西药治疗稳定型心绞痛的临床疗效观察  

Clinical Observation of Medicine Partition Moxibustion on Shendao Bazhen Acupoints Combined with Western Medicine in Treating Stable Angina Pectoris

作　　者：陈科[1] 王伟贵 张巧娜 吴双 霍丹 CHEN Ke;WANG Wei-Gui;ZHANG QiaO-Na;WU Shuang;HUO Dan(Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000 Hebei,China)

机构地区：[1]唐山市中医医院,河北唐山063000

出　　处：《广州中医药大学学报》2021年第6期1173-1180,共8页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：河北省中医药管理局中医药类科研资助项目(编号:2020379)。

摘　　要：【目的】观察神道八阵穴隔药灸联合西药治疗稳定型心绞痛的临床疗效,并探讨其可能的作用机制。【方法】将68例气虚血瘀型稳定型心绞痛患者随机分为观察组和对照组,每组各34例。2组均给予常规西药治疗,对照组给予隔药灸治疗,观察组给予神道八阵穴隔药灸治疗。每日1次,每周5次,共治疗4周。治疗4周后,观察2组患者治疗前后中医证候评分、心绞痛症状评分、西雅图心绞痛量表评分的变化情况,并比较心电图QT离散度、心率变异性,以及血液流变学及血管内皮功能的变化情况,评价2组的安全性,并比较2组患者的中医证候疗效及心绞痛临床疗效。【结果】(1)观察组中医证候疗效总有效率为91.18%(31/34),对照组为73.53%(25/34),观察组优于对照组(P<0.05)。(2)观察组心绞痛临床疗效总有效率为88.24%(30/34),对照组为70.59%(24/34),观察组优于对照组(P<0.05)。(3)治疗后,2组患者的西雅图心绞痛量表各项评分均明显改善(P<0.05),且观察组明显优于对照组,差异有统计学意义(P<0.05)。(4)治疗后,2组患者的QT离散度、心率变异性均明显改善(P<0.05),且观察组明显优于对照组,差异有统计学意义(P<0.05)。(5)治疗后,2组患者的血浆黏度、全血高切黏度、全血中切黏度、全血低切黏度均明显改善(P<0.05),且观察组明显优于对照组,差异有统计学意义(P<0.05)。(6)治疗后,2组患者的血清一氧化氮(NO)、血管内皮生长因子(VEGF)及内皮素1(ET-1)均明显改善(P<0.05),且观察组优于对照组,差异有统计学意义(P<0.05)。(7)2组患者治疗前后血、尿、大便常规,肝、肾功能,血糖检查均无明显异常。【结论】神道八阵穴隔药灸联合西药治疗稳定型心绞痛疗效确切,可有效改善机体血液流变学及血管内皮功能。Objective To observe the clinical efficacy of medicine partition moxibustion on Shendao Bazhen acupoints combined with western medicine for the treatment of stable angina pectoris,and to explore its possible action mechanism. Methods Sixty-eight patients with stable angina pectoris of qi deficiency and blood stasis type were randomly divided into observation group and control group,34 cases in each group. The two groups received routine western medicine,additionally,the control group received medicine partition moxibustion treatment,and the observation group received medicine partition moxibustion on Shendao Bazhen acupoints treatment, once a day, 5 times a week, the treatment lasting 4 weeks. After 4 weeks of treatment, the changes of traditional Chinese medicine(TCM)syndrome score,angina symptom score,Seattle Angina scale score were observed in the two groups before and after treatment, the changes in QT dispersion, heart rate variability(HRV),hemorheology and vascular endothelial function of the two groups were compared,and the safety of the two groups was evaluated,and the therapeutic efficacy of TCM syndrome and clinical symptoms of angina pectoris of the two groups were compared. Results(1)The total effective rate of TCM syndrome in the observation group was 91.18%(31/34), and that in the control group was 73.53%(25/34), the clinical efficacy for TCM syndrome of the observation group being superior to that of the control group(P < 0.05).(2)The total effective rate of angina pectoris was 88.24%(30/34)in the observation group and 70.59%(24/34)in the control group, the clinical efficacy for angina pectoris of the observation group being superior to that of the control group(P < 0.05).(3)After treatment, the Seattle Angina scale scores of the two groups were significantly improved(P < 0.05), and the improvement of the observation group was significantly superior to that of the control group,the difference being statistically significant(P < 0.05).(4)After treatment,QT dispersion and heart rate variability of th

关 键 词：神道八阵穴 隔药灸 稳定型心绞痛 血液流变学 血管内皮功能 心率变异性 

分 类 号：R246.9[医药卫生—针灸推拿学]