冰片衍生物对血脑屏障通透性影响的研究  

Studies on Effect of Borneol Derivatives on Blood-Brain-Barrier Permeability

作　　者：陈传兵[1] 刘昌辉[1] 伍海涛[1] 张荣[1] 赵威[1] 李伟荣[1] 杨蕾[1] 宓穗卿[1] 王宁生[1] CHEN Chuan-Bing;LIU Chang-Hui;WU Hai-Tao;ZHANG Rong;ZHAO Wei;LI Wei-Rong;YANG Lei;MI Sui-Qing;WANG Ning-Sheng(Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510405

出　　处：《广州中医药大学学报》2021年第6期1214-1216,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：社会发展领域科技计划项目(编号:011B031700069);广东省中药有效性与安全性研究重点实验室开放基金资助项目(编号:kf07005);广州中医药大学创新基金资助项目(编号:2007C002)。

摘　　要：【目的】探讨10种合成的冰片衍生物对血脑屏障通透性的影响。【方法】采用多功能酶标仪检测小鼠脑组织中伊文思蓝的含量来评价2-氯苯甲酸冰片酯、3,5-二硝基苯甲酸冰片酯、3-硝基苯甲酸冰片酯、4-硝基苯甲酸冰片酯、1-萘乙酸冰片酯、4-氯苯甲酸冰片酯、苯甲酸冰片酯、3-甲基苯甲酸冰片酯、4-甲基苯甲酸冰片酯、三氯乙酸冰片酯10种冰片衍生物的血脑屏障通透性效果。【结果】酶标仪法测定结果显示,10种冰片衍生物中只有2-氯苯甲酸冰片酯的血脑屏障通透性效果显著优于右旋冰片组(阳性对照),两者具有显著性差异(P <0.001)。【结论】2-氯苯甲酸冰片酯对血脑屏障通透性具有促进作用。Objective To explore the effect of 10 kinds of bornoel derivatives on blood-brain-barrier permeability.Methods A multifunctional-enzyme labeled instrument was used to determine the content of Evens blue in mice brain tissues to evaluate the effect of 10 bornoel derivatives such as bornyl 2-chlorobenzoate, bornyl 3,5-dinitrobenzoate, bornyl 3-nitrobenzoate, bornyl 4-nitrobenzoate, bornyl 1-naphthylacetate, bornyl 4-chlorobenzoate,bornyl benzoate,bornyl 3-methylbenzoate,bornyl 4-methylbenzoate,bornyl trichloroacetate on blood-brain-barrier permeability. Results The result showed that only the effect of bornyl 2-chlorobenzoate in 10 bornoel derivatives on blood-brain-barrier permeability was superior to bornoel group(as positive control)by enzyme-labeled instrument,the difference being significant(P < 0.001). Conclusion Bornyl 2-chlorobenzoate is effective for promoting blood-brain-barrier permeability.

关 键 词：冰片 衍生物 血脑屏障 小鼠 

分 类 号：K285.5[历史地理—历史学]