补肾活血中药联合来曲唑治疗PCOS不孕症疗效的Meta分析  

Meta Analysis of the Treatment of Infertility in Polycystic Ovary with Chinese Herbal Medicines for Tonifying Kidney and Activating Blood Combined with Letrozole

作　　者：盛楠 曹梦娣 赵薇[2] SHENG Nan;CAO Mengdi;ZHAO Wei(Nanjing University of Chinese Medicine,Nanjing 210023,China;Nanjing Hospital of Chinese Medicine,Nanjing 210001,China)

机构地区：[1]南京中医药大学,江苏南京210023 [2]南京中医药大学附属南京中医院,江苏南京210001

出　　处：《中国民族民间医药》2021年第10期53-58,共6页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:系统评价补肾活血中药联合来曲唑治疗多囊卵巢综合征不孕症的疗效。方法:检索CNKI、Wan Fang Data、VIP、PubMed和CBM数据库,查找补肾活血中药联合来曲唑治疗多囊卵巢综合征不孕症临床疗效观察的随机对照试验。采用Rev Man5.3软件进行Meta分析。结果:最终纳入文献9篇,共810例患者,其中补肾活血中药联合来曲唑治疗组450例,单用来曲唑对照组360例;在改善总有效率、妊娠率、子宫内膜厚度、LH(促黄体生成激素)、FSH(促卵泡生成激素)水平方面,补肾活血中药联合来曲唑组优于单用来曲唑组(P<0.05);治疗组不良反应发生率低于对照组,安全性更高(P<0.05)。结论:与单纯来曲唑治疗相比,补肾活血中药联合来曲唑可有效改善多囊卵巢综合征不孕症患者的临床症状,提高治疗总有效率、妊娠率,增加子宫内膜厚度,改善LH、FSH水平,且安全性较高。Objective To evaluate the efficacy of kidney-tonifying and blood-activating herbs combined with letrozole in treating PCOS(Polycystic ovary syndrome)infertility.Methods To collect the randomized controlled trials about the clinical effect of treatment of PCOS infertility with kidney-tonifying and blood-activating herbs combined with letrozole by retrieval of CNKI,Wan Fang,VIP,PubMed and CBM databases.Meta analysis was carried out by Rev Man 5.3 software.Results A total of 9 articles were included.Totally 810 cases were included,including 450 in the treatment group and 360 in the control group;In terms of improving the total effective rate,pregnancy rate,endometrial thickness,LH levels,FSH levels,the treatment group is better than the control group(P<0.05);The adverse reactions of treatment groups was lower than that of control group(P<0.05).Conclusion Compared with letrozole treatment alone,the kidney-tonifying and blood-activating herbs combined with letrozole can effectively improve the clinical symptoms of patients with PCOS infertility,improve the total effective rate,pregnancy rate,increase the thickness of the endometrium,and regulate the levels of LH and FSH,and have a high safety.

关 键 词：补肾活血 来曲唑 多囊卵巢综合征 不孕症 META分析 

分 类 号：R259[医药卫生—中西医结合]