急性心肌梗死标志物化学发光和电化学发光分析研究进展  

Recent Advances in Chemiluminescence and Electrochemiluminescence Assays of Acute Myocardial Infarction Biomarkers

作　　者：陈业权 全帅 杜芳昕 娄保华[2,3] 李建平 徐国宝[1,2,3] CHEN Ye-Quan;QUAN Shuai;DU Fang-Xin;LOU Bao-Hua;LI Jian-Ping;XU Guo-Bao(College of Chemistry and Bioengineering,Guilin University of Technology,Guilin 541004,China;State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;University of Science and Technology of China,Hefei 230022,China)

机构地区：[1]桂林理工大学化学与生物工程学院,桂林541004 [2]中国科学院长春应用化学研究所电分析化学国家重点实验室,长春130022 [3]中国科学技术大学,合肥230022

出　　处：《分析化学》2021年第6期849-857,共9页Chinese Journal of Analytical Chemistry

基　　金：国家重点研发计划项目(No.2016YFA0201303);国家自然科学基金项目(No.21874126);吉林省科学技术厅项目(No.20200703024ZP)资助。

摘　　要：化学发光和电化学发光分析具有灵敏度高、分析快速和操作简便等优点,广泛用于临床诊断、药物分析、食品检测和环境监测等领域。本文对近三年化学发光和电化学发光分析在检测急性心肌梗死标志物中的研究进展进行了评述,分析了心肌肌钙蛋白、肌红蛋白、心脏型脂肪酸结合蛋白、肌酸激酶同工酶MB和肽素以及心脏特异性microRNAs等生物标志物的诊断价值,探讨了化学发光和电化学发光生物传感器的构建和应用优势,并对其未来发展趋势进行了展望。Chemiluminescence(CL)and electrochemiluminescence(ECL)assays are widely utilized in clinical diagnosis,drug analysis,food testing,environmental monitoring and other fields because of their superiorities of high sensitivity,rapid analysis and facile operation.In this review,the recent advances of CL and ECL assays of acute myocardial infarction biomarkers were emphatically summarized.The diagnostic value of cardiac troponin,myoglobin,heart type fatty acid-binding protein,creatine kinase MB,copeptin and myocardial specific microRNAs as biomarkers were compared.The fabrication and application advantages of these Cl and ECL biosensors were discussed.Furthermore,the further research orientations were also prospected.

关 键 词：急性心肌梗死 生物标志物 化学发光 电化学发光 评述 

分 类 号：O657[理学—分析化学] R542.22[理学—化学]