心泵辅助装置研究进展及动物实验质量控制  

Progress of Heart Pump Assist Device and Quality Control in Animal Experiments

作　　者：崔永春[1] 王小康 周建业[1] 杨伯清 彭鹏 贾六军[1] 孟亮 李彬[1] 罗佳菲 袁卫民[1] 周燕文 杜红 李秋菊 李悦[1] 李巨波[1] 岳广新 王欣[1] CUI Yong-chun;WANG Xiao-kang;ZHOU Jian-ye;YANG Bo-qing;PENG Peng;JIA Liu-jun;MENG Liang;LI Bin;LUO Jia-fei;YUAN Wei-min;ZHOU Yan-wen;DU Hong;LI Qiu-ju;LI Yue;LI Ju-bo;YUE Guang-xin;WANG Xin(Peking Union Medical College,Beijing Key Laboratory of Cardiovascular Implant Materials Preclinical Research Evaluation,Animal Experiment Center,Fuwai Hospital,Chinese Academy of Medical Sciences,State Key Laboratory of Cardiovascular Diseases,Beijing 100037)

机构地区：[1]北京协和医学院,心血管植入材料临床前研究评价北京市重点实验室,动物实验中心,阜外医院,中国医学科学院,心血管疾病国家重点实验室,北京100037

出　　处：《中国医疗器械信息》2021年第9期45-49,共5页China Medical Device Information

基　　金：北京市自然科学基金面上项目(项目编号:7172181);心血管植入材料临床前研究评价北京市重点实验室主任基金(项目编号:2018-PT2-ZR04);国家自然科学基金面上项目(项目编号:81970387);北京市科委科技支撑项目(项目编号:Z101107052210004);政府间国际科技创新合作重点专项(项目编号:2018YFE0114900)。

摘　　要：心泵辅助装置是目前临床治疗心脏功能不全的常用辅助装置。文章就心泵辅助装置的国内外研究现状,综述了新一代主动脉内球囊反搏、静脉-动脉体外膜式氧合器、左心辅助装置和全人工心脏的结构和功能特点、优点和不足,并对其临床应用现状进行了比较分析。同时,结合文献报道和国家相关标准对植入式心室辅助装置的临床前研究动物实验的质量控制要点进行了阐述,以期为新型心泵辅助装置的研发提供参考与支持。Heart pump assist device(HPAD)is currently a commonly used assist device for clinical patients with cardiac dysfunction.This article summarizes the current research status of HPAD at home and abroad,reviews the structural and functional characteristics,advantage and disadvantage of the newest generation of intra-aortic balloon pump(IABP),venoarterial extracorporeal membrane oxygenation(ECMO),left ventricular assist devices(LVAD)and total artificial heart(TAH),and makes a comparative analysis of their current clinical applications.Moreover,combined with literature reports and relevant national standards,the quality control points of the preclinical animal experiments of implantable ventricular assist devices are described,aiming at providing reference and support for the research and development of new HPADs.

关 键 词：主动脉内球囊反搏 静脉-动脉体外膜式氧合器 左心辅助装置 全人工心脏 动物实验 质量控制 

分 类 号：TH778[机械工程—仪器科学与技术]