吡啶碱合成工艺研究  

Study on Continuous Synthesis Process of Pyridine Base

作　　者：刘敏 张强 孙玉栋 鲁宁宁 王婕 LIU Min;ZHANG Qiang;SUN Yu-dong;LU Ning-ning;WANG Jie(Anhui Costar Biological Chemical Co.Ltd.,Anhui Heterocyclic Chemistry Provincial Laboratory,Maanshan 243100,China)

机构地区：[1]安徽国星生物化学有限公司安徽杂环化学省级实验室,安徽马鞍山243100

出　　处：《安徽化工》2021年第3期69-71,共3页Anhui Chemical Industry

摘　　要：以CoSAPO-34分子筛为催化剂,固定床为反应器,采用醛氨法合成吡啶碱。系统考查了Co含量、催化剂用量、原材料摩尔比、反应温度、反应压力的影响,筛选出合适的反应条件。反应的最优条件为CoO∶Al_(2)O_(3)摩尔比0.7,催化剂用量8%,甲醛∶乙醛∶氨气1.2∶1∶2.6,反应温度为400℃,反应压力0.5 MPa,此时吡啶碱收率达86.7%。该工艺操作简单,安全性高,收率高,适合工业化生产。The pyridine base was synthesized by using the formaldehyde,acetaldehyde and ammonia as raw material in fixed bed reactor.The influence of CoO∶Al_(2)O_(3)ratio,catalyst amount,residence temperature and pressure,ratio of the raw materials was systematically investigated,and suitable reaction conditions were selected.The optimal conditions for diazoti⁃zation were as follows:the ratio of CoO∶Al_(2)O_(3)was 0.7,the amount of catalyst was 8%,the ratio of raw materials was 1.2∶1∶2.6,the temperature was 400℃,and the pressure was 0.5 MPa,the yield pyridine base was 86.7%.The process realizes the continuous synthesis of pyridine base has high safety and high yield,and is suitable for industrial production.

关 键 词：CoSAPO-34 分子筛 醛氨法 固定床 吡啶碱 

分 类 号：TQ253.2[化学工程—有机化工]