芜湖地区新生儿疾病患者血清弓形虫抗体调查  

Research on antibodies of Toxoplasma gondii in serums among patients with newborn infant disease in Wuhu area

作　　者：朱志伟 方芳[2] 赵金红[1] 薛琪琪 邹茗惠 张炎[1] 吴燕 ZHU Zhi-wei;FANG Fang;ZHAO Jin-hong;XUE Qi-qi;ZOU Ming-hui;ZHANG Yan;WU Yan(Laboratory of Human Parasitology,Wannan Medical College,Wuhu Anhui241002,China;不详)

机构地区：[1]皖南医学院人体寄生虫学教研室,安徽芜湖241002 [2]皖南医学院弋矶山医院检验科

出　　处：《医学动物防制》2021年第5期509-510,F0003,共3页Journal of Medical Pest Control

基　　金：省高校学科(专业)拔尖人才学术资助项目(gxbjZD2020071);省自然科学基金面上项目(1608085MC77);省高校优秀青年人才支持计划重点项目(gxyqZD2016171)。

摘　　要：目的了解芜湖地区近5年就诊和住院新生儿弓形虫病感染情况。方法应用电化学发光免疫分析法(electrochemiluminescence immunoassay,ECLIA)对3371例新生儿血清中的TOX-IgM和TOX-IgG特异性抗体进行检测。结果芜湖地区3371例新生儿血清中2例呈TOX-IgM阳性,阳性率为0.06%(2/3371),TOX-IgG阳性率为13.02%(439/3371);2例TOX-IgM阳性者均为男性新生儿,阳性率为0.11%(2/1904),其TOX-IgG阳性率为12.29%(234/1904),女性新生儿TOX-IgM阳性率为0%,其TOX-IgG阳性率为13.97%(205/1467),男女性新生儿TOX-IgM及TOX-IgG阳性率差异无统计学意义(P>0.05)。早产儿、新生儿高胆红素血症、新生儿ABO溶血、呼吸窘迫综合征和小于胎龄儿5类特殊新生儿TOX-IgG阳性率分别为8.06%、11.08%、63.01%、11.48%和7.92%,其中仅早产儿和新生儿ABO溶血患者与健康对照者差异有统计学意义(χ^(2)=11.79,P<0.01;χ^(2)=161.86,P<0.01)。结论芜湖地区新生儿弓形虫TOX-IgG阳性率较高,TOX-IgM阳性率较低,说明新生儿感染弓形虫病主要是其母亲垂直传播所引起,临床上应加强孕妇及其新生儿弓形虫抗体检测筛查,为弓形虫病的诊断治疗提供相关依据。Objective To understand the infection status of Toxoplasma gondii infected in newborns which visits and hospitalizations in Wuhu area in the past 5 years.Methods Electrochemiluminescence immunoassay(ECLIA)was used to detect specific antibodies of TOX-IgM and TOX-IgG in serums of 3371 newborns.Results In the 3371 neonatal sera in Wuhu area,only 2 cases were found to be TOX-IgM positive with the positive rate was 0.06%(2/3371),and the positive rate of TOX-IgG hit 13.02%(439/3371);2 patients with TOX-IgM were male newborns with the positive rate of 0.11%(2/1904),the positive rate of TOX-IgG hit 12.29%(234/1904),the positive rate of TOX-IgM in female newborns was 0%,and the positive rate of TOX-IgG was 13.97%(205/1467),and the difference in the positive rate of TOX-IgM and TOX-IgG between male and female newborns wasn’t statistically significant(P>0.05).The positive rate of TOX-IgG of 5 special newborns involving premature and neonatal hyperbilirubinemia,neonatal ABO hemolysis,respiratory distress syndrome,and small-for-gestational age infants were 8.06%,11.08%,63.01%,11.48%and 7.92%respectively,and only the differences in only premature infants and newborns with ABO hemolysis and healthy controlled newborns were statistically significant(χ^(2)=11.79,P<0.01;χ^(2)=161.86,P<0.01).Conclusion The positive rate of TOX-IgG of neonatal Toxoplasma gondii in Wuhu area is relatively high,and positive rate of TOX-IgM is low,indicating neonatal toxoplasmosis infection is mainly caused by maternally vertical transmission,and testing and screening of Toxoplasma antibody on pregnant women and their newborns should be strengthened in clinical practice to provide relevant evidences for diagnosis and treatment of Toxoplasma gondii.

关 键 词：弓形虫 新生儿 电化学发光免疫分析法 抗体 调查 

分 类 号：R531.8[医药卫生—内科学]