三花飞扬溶液外用治疗湿疹的临床研究  

Clinical Study on External Application of Sanhua Feiyang Solution for the Treatment of Eczema

作　　者：郭樱[1] 杨玉峰[1] 胡文娟 刘少芬[1] 钟玲玲 GUO Ying;YANG Yu-Feng;HU Wen-Juan;LIU Shao-Fen;ZHONG Ling-Ling(Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033 Guangdong,China)

机构地区：[1]深圳市中医院,广东深圳518033

出　　处：《广州中医药大学学报》2021年第5期925-930,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20191277)。

摘　　要：【目的】研究三花飞扬溶液外用治疗湿疹的临床疗效和复发情况。【方法】将60例湿疹患者随机分为治疗组和对照组,每组各30例。治疗组给予外用三花飞扬溶液治疗,对照组给予外用糠酸莫米松乳膏治疗,疗程为4周。观察2组患者治疗前后湿疹面积及严重度指数(EASI)、视觉模拟量表(VAS)、研究者总体评估(IGA)评分的变化情况,比较2组患者的临床疗效、复发情况和安全性。【结果】(1)治疗4周后,治疗组的愈显率为83.3%(25/30),对照组为50.0%(15/30),组间比较,治疗组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗1周后,2组患者的EASI、IGA、VAS评分均较治疗前下降,但差异均无统计学意义(P>0.05);治疗4周后,2组患者的EASI、IGA、VAS评分均较治疗前和治疗1周后明显下降,差异均有统计学意义(P<0.05);组间比较,治疗组在治疗4周后对EASI、IGA、VAS评分的下降作用均明显优于照组,差异均有统计学意义(P<0.05或P<0.01)。(3)治疗5周后随访,治疗组的复发率为10.0%(3/30),明显低于对照组的40.0%(12/30),差异有统计学意义(P<0.01)。(4)治疗过程中,2组患者均无明显不良反应发生,具有较高的安全性。【结论】三花飞扬溶液外用治疗湿疹疗效确切,复发率低,且无明显不良反应。Objective To study the clinical effect of external treatment with Sanhua Feiyang Solution for eczema and to observe the recurrence.Methods Sixty patients with eczema were randomly divided into treatment group and control group,30 cases in each group.The treatment group was given topical application of Sanhua Feiyang Solution,and the control group was given topical use of Mometasone Furoate Cream.The two groups were simultaneously treated for 4 continuous weeks as a course of treatment.Before and after treatment,the scores of eczema area and severity index(EASI),visual analogue scale(VAS)scores,and the scores of investigator’s global assessment(IGA)in the two groups were observed.After treatment,the clinical efficacy,recurrence rate,and safety between the two groups were compared.Results(1)After treatment for 4 weeks,the cured and effective rate in the treatment group was 83.3%(25/30),and that in the control group was 50.0%(15/30).The intergroup comparison showed that the clinical efficacy in the treatment group was stronger than that in the control group,and the difference was statistically significant(P<0.05).(2)After treatment for one week,the scores of EASI,IGA,and VAS in the two groups were decreased,but the differences were not statistically significant in comparison with those before treatment(P>0.05).After treatment for 4 weeks,the scores of EASI,IGA,and VAS in the two groups were obviously lower than those before treatment and those after treatment for one week,and the differences were statistically significant(P<0.05).The intergroup comparison showed that the treatment group had stronger effect on decreasing the scores of EASI,IGA,and VAS than the control group after treatment for 4 weeks,and the differences were statistically significant(P<0.05 or P<0.01).(3)The results of follow-up5 weeks after the medication showed that the recurrence rate of the treatment group was10.0%(3/30),and was much lower than that in the control group[40.0%(12/30)],the differences being statistically significant(P<0.01).(4)D

关 键 词：湿疹 三花飞扬溶液 糠酸莫米松乳膏 外用 临床研究 

分 类 号：R275.9[医药卫生—中西医结合]