针刺联合益肾熄风汤治疗肝肾阴虚型帕金森病的临床研究  

Clinical Study on Acupuncture Combined with Kidney-Nourishing and Wind-Suppressing Decoction for Treatment of Parkinson’s Disease of Liver-Kidney Yin Deficiency Type

作　　者：郑卜通 张光彩[1] 周晓晖[1] 冯琦钒 ZHENG Bu-Tong;ZHANG Guang-Cai;ZHOU Xiao-Hui;FENG Qi-Fan(Hainan Provincial Hospital of Traditional Chinese Medicine,Haikou 570203 Hainan,China)

机构地区：[1]海南省中医院,海南海口570203

出　　处：《广州中医药大学学报》2021年第5期934-940,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(编号:816615046);海南省卫生计生行业科研项目(编号:19A200175)。

摘　　要：【目的】观察针刺联合益肾熄风汤治疗肝肾阴虚型帕金森病的临床疗效。【方法】将98例肝肾阴虚型帕金森病患者随机分为观察组和对照组,每组各49例,对照组给予多巴丝肼片口服,每次1片,每日3次。观察组在对照组治疗的基础上,给予针刺及益肾熄风汤治疗。2组均连续治疗12周。治疗12周后,评价2组患者的临床疗效,观察2组患者治疗前后血清同型半胱氨酸(Hcy)、胱抑素C(Cys-C)以及神经营养因子3(NT-3)的变化情况,以及血清5-羟色胺(5-HT)、谷胱甘肽过氧化酶(GSH-Px)、多巴胺(DA)的情况,比较2组患者治疗前后帕金森病生活质量量表(PDQ-39)、帕金森病评分量表(UPDRS)评分的变化情况。并评价2组的安全性及不良反应发生情况。【结果】(1)治疗后,2组患者的血清Hcy、Cys-C、NT-3水平均明显改善(P<0.05),且观察组在改善血清Hcy、Cys-C、NT-3水平方面明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的血清5-HT、GSH-Px、DA水平明显改善(P<0.05),且观察组在改善血清5-HT、GSH-Px、DA水平方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的UPDRS、PDQ-39评分明显改善(P<0.05),且观察组在改善UPDRS、PDQ-39评分方面明显优于对照组,差异有统计学意义(P<0.05)。(4)观察组总有效率为93.88%(46/49),对照组为73.47%(36/49)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(5)观察组不良反应总发生率为16.33%(8/49),对照组为18.37%(9/49),观察组与对照组的不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】针刺联合益肾熄风汤治疗肝肾阴虚型帕金森病,有助于减轻患者的氧化应激失衡,调节神经递质水平,改善患者的临床症状,从而提高患者的生活质量,临床疗效显著。Objective To observe the clinical therapeutic effect of acupuncture combined with Kidney-Nourishing and Wind-Suppressing Decoction for Parkinson’s disease of liver-kidney yin deficiency type.Methods Ninetyeight patients with Parkinson’s disease of liver-kidney yin deficiency type were randomly divided into observation group and control group,49 cases in each group.The patients of both groups received oral use of Levodopa and Benserazide Hydrochloride Tablets,one tablet every time,3 times per day,additionally,the observation group received acupuncture combined with Kidney-Nourishing and Wind-Suppressing Decoction.The treatment lasted12 weeks.After 12 weeks of treatment,the clinical efficacy of the two groups was evaluated,the changes of serum homocysteine(Hcy),cystatin C(Cys-C)and neurotrophic factor 3(NT-3),5-hydroxytryptamine(5-HT),glutathione peroxidase(GSH-Px),dopamine(DA)were observed in the two groups before and after treatment,and the changes of Quality of Life Scale for Parkinson’s Disease(PDQ-39)and Parkinson’s Disease Score Scale(UPDRS)were compared between the two groups before and after treatment.Results(1)After treatment,the serum Hcy,Cys-C,NT-3 levels were significantly improved in the two groups(P<0.05),and the improvement in serum Hcy,Cys-C,NT-3 levels of the observation group was significantly superior to that of the control group,the difference being statistically significant(P<0.05).(2)After treatment,the serum 5-HT,GSH-Px,DA levels were significantly improved in the two groups(P<0.05),and the improvement in serum 5-HT,GSH-Px,DA levels of the observation group was significantly superior to that of the control group,the difference being statistically significant(P<0.05).(3)After treatment,the UPDRS,PDQ-39 scores were significantly improved in the two groups(P<0.05),and the improvement in UPDRS,PDQ-39 scores of the observation group was significantly superior to that of the control group,the difference being statistically significant(P<0.05).(4)The total effective rate in the observation g

关 键 词：针刺 益肾熄风汤 帕金森病 肝肾阴虚型 氧化应激 神经递质 生活质量 

分 类 号：R246.9[医药卫生—针灸推拿学]