局灶节段性肾小球硬化型肾病综合征患儿中药治疗用药规律分析  

Investigation of Medication Rule of Chinese Medicine Treatment for Pediatric Nephrotic Syndrome with Focal Segmental Glomerulosclerosis

作　　者：李亚美[1] 李荣贞 陈乃清[2] 温晓莹 张丽娇 曾维嘉[2] LI Ya-Mei;LI Rong-Zhen;CHEN Nai-Qing;WEN Xiao-Ying;ZHANG Li-Jiao;ZENG Wei-Jia(Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;LUO Xiao-Rong Famous Physician Studio,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120 Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广东省中医院罗笑容名医工作室,广东广州510120

出　　处：《广州中医药大学学报》2021年第5期1055-1060,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局专项资助课题(编号:20191161);国家中医药管理局科研课题:罗笑容全国名老中医药专家传承工作室建设项目(编号:14GG2X02)。

摘　　要：选取2012年9月至2019年12月在广东省中医院儿科住院部采用中药治疗的局灶节段性肾小球硬化(FSGS)型肾病综合征的有效病案,建立中医药治疗FSGS型肾病综合征的文献研究数据库,运用中医传承辅助平台(V2.5)的频数分析、聚类分析以及关联分析等数据挖掘方法对中药治疗FSGS型肾病综合征的用药规律进行挖掘。结果共得到中药治疗FSGS型肾病综合征的处方299首,中药129味;药物主要可归为补虚药、解表药、利水渗湿药、化痰止咳平喘药、理气药、温里药、清热药等类别。药物的五味以甘、辛、苦为主,药性多温、平、寒;归经以肺经、脾经为主。对高频药物进行聚类分析,结果共得到8个聚类组合;对药物进行关联规则分析,得到频数在60次以上的药物组合共17组,置信度大于0.8的药物关联规则11条。结果提示中药治疗FSGS型肾病综合征患儿,药物五味以甘、辛、苦为主,药性多温、平、寒;归经以肺经、脾经为主;核心药物为甘草、白术、茯苓、玉米须、白芍等。临床治疗原则遵循急则治其标,以宣肺解表祛邪、利尿渗湿消肿为主;缓则治其本,宜健脾为主,佐以温升、理气之品。The information of medical record of effective cases of pediatric nephrotic syndrome with focal segmental glomerulosclerosis(FSGS) treated with Chinese medicine in the pediatric inpatient department of Guangdong Provincial Hospital of Traditional Chinese Medicine from September 2012 to December 2019 was collected and screened. And then the literature database of Chinese medicine for the treatment of FSGS pediatric nephrotic syndrome was established. By using the frequency analysis, cluster analysis, and association rule analysis in the Traditional Chinese Medicine Inheritance Support System(V2.5),we mined the medication rule of Chinese medicine for the treatment of FSGS pediatric nephrotic syndrome. A total of 299 prescriptions involving129 herbs for the treatment of FSGS pediatric nephrotic syndrome were obtained. The 129 herbs can be mainly classified into the categories of herbs for tonifying deficiency, herbs for releasing exterior, herbs for inducing diuresis and draining dampness, herbs for resolving phlegm, easing cough and relieving asthma, herbs for regulating qi, herbs for warming the interior, and herbs for clearing heat. The flavors of the herbs in the prescriptions for the treatment of FSGS pediatric nephrotic syndrome were characterized by sweet,pungent and bitter herbs,and the properties of the herbs were characterized by being warm,mild and cold. The herbs usually had the meridian tropism to lung meridian and spleen meridian. Cluster analysis results showed that high-frequency8 clustered recipes were obtained. A total of 17 herbal combinations with the frequency over 60 times were mined out by using association rule analysis, and 11 herbal association rules with the confidence over 0.8 were also obtained. The data mining results indicated that for the treatment of FSGS pediatric nephrotic syndrome with Chinese medicine,the sweet,pungent and bitter herbs with the warm,mild and cold properties and with the meridian tropism to lung meridian and spleen meridian are usually adopted. The core herbs for

关 键 词：局灶节段性肾小球硬化 儿童肾病综合征 用药规律 宣肺解表 利尿渗湿 健脾 

分 类 号：R256.5[医药卫生—中医内科学]