百令胶囊联合缬沙坦治疗糖尿病肾病临床疗效及安全性的Meta分析  

Meta-analysis of Clinical Efficacy and Safety of Bailing Capsules Combined with Valsartan in the Treatment of Diabetic Kidney Disease

作　　者：龚丽 黄寅銮 谢韶妍 陈玉甜 王桂娟 谢君成 GONG Li;HUANG Yin-Luan;XIE Shao-Yan;CHEN Yu-Tian;WANG Gui-Juan;XIE Jun-Cheng(Dept,of Diabetes,Bao'an Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine,Shenzhen 518100 Guangdong,China;Guangzhou University of Chinese Medicine,Guangzhou 518100 Guangdong,China)

机构地区：[1]广州中医药大学附属宝安中医院糖尿病科,广东深圳518100 [2]广州中医药大学,广东广州518100

出　　处：《广州中医药大学学报》2021年第5期1061-1066,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局资助项目(编号:20201316);宝安区医疗卫生基础研究项目(编号:2020JD511)。

摘　　要：【目的】采用Meta分析评价百令胶囊联合缬沙坦治疗糖尿病肾病患者的临床疗效和安全性。【方法】收集中国知网(CNKI)、维普(VIP)中文科技期刊数据库、万方(Wanfang)数据库、中国生物医学文献服务系统(SinoMed)、PubMed、Embase数据库中百令胶囊联合缬沙坦(观察组)对比单用缬沙坦(对照组)治疗糖尿病肾病的临床随机试验,采用Cochrane系统对文献进行质量评估,以RevMan5.3软件对多项研究结果的总体效应进行Meta分析。【结果】共纳入10项研究,合计782例患者。Meta分析结果显示:与单独使用缬沙坦比较,百令胶囊联合缬沙坦治疗可显著降低糖尿病肾病患者24 h尿蛋白量[MD=-1.71,95%CI(-2.30,-1.12),P<0.000 01]、血肌酐[MD=-13.24,95%CI(-23.81,-2.68),P=0.01]、血尿素氮[MD=-1.43,95%CI(-1.68,-1.18),P<0.000 01],且无明显不良反应。【结论】百令胶囊联合缬沙坦治疗糖尿病肾病疗效确切且较安全。由于目前纳入文献数量不多且文献质量一般,此结论需要谨慎对待,今后需更多高质量的随机对照试验支持。Objective To evaluate the clinical efficacy and safety of Bailing Capsules combined with valsartan in the treatment of diabetic kidney disease(DKD)with meta-analysis.Methods Data of clinical randomized trials of Bailing Capsules combined with valsartan(observation group)vs valsartan alone(control group)for the treatmen of DKD in the databases of CNKI,VIP,Wanfang,Sino Med,Pub Med and Embase were collected.Cochrane systematic review was used to evaluate the quality of the articles.Rev Man 5.3 software was used to analyze the overall effect of included trials.Results A total of 10 studies involving 782 cases of DKD were included.The results of meta-analysis showed that Bailing Capsules combined with valsartan could significantly reduce 24-hour urinary protein[MD=-1.71,95%CI(-2.30,-1.12),P<0.000 01],serum creatinine[MD=-13.24,95%CI(-23.81,-2.68),P=0.01],blood urea nitrogen[MD=-1.43,95%CI(-1.68,-1.18),P<0.000 01]as compared with valsartan alone,and showed no obvious adverse reactions.Conclusion Bailing Capsules combined with valsartan are effective and safe in treating diabetic kidney diseases.But for the amount of the included articles is not enough and the quality of the studies is not high,the conclusion needs to be carefully considered and still need to be verified by more high-quality randomized controlled trials.

关 键 词：百令胶囊 缬沙坦 糖尿病肾病 24 h尿蛋白量 血肌酐 血尿素氮 META分析 

分 类 号：R255.4[医药卫生—中医内科学] R587.2[医药卫生—中医学]