渭南市2017年手足口病病原学监测结果分析  

Analysis on etiological surveillance results of hand-foot-mouth disease in Weinan in 2017

作　　者：魏明敏[1] 王露婕 马宁[1] 张系忠 刘玮[1] 赵爱珠 沈托[1] 魏惠琴[1] 杨欢欢[1] 焦莉萍[1] 杨云云[1] WEI Ming-min;WANG Lu-jie;MA Ning;ZHANG Xi-zhong;LIU Wei;ZHAO Ai-zhu;SHEN Tuo;WEI Hui-qin;YANG Huan-huan;JIAO Li-ping;YANG Yun-yun(Weinan Center for Disease Control and Prevention,Shaanxi 714000,China)

机构地区：[1]渭南市疾病预防控制中心,陕西714000

出　　处：《医学动物防制》2021年第2期103-106,111,共5页Journal of Medical Pest Control

基　　金：陕西省社会发展科技攻关项目——手足口病分子流行病学及病原谱遗传变异特征的研究(2015SF187)。

摘　　要：目的对渭南市2017年手足口病(hand-foot-mouth disease,HFMD)实验室检测结果进行分析,了解该市手足口病病原特征,为手足口病防控提供病原学依据。方法应用实时荧光定量PCR(Real-time PCR,RT-PCR)法对渭南市2017年785份疑似手足口病标本进行肠道病毒71型(Enterovirus 71,EV 71),柯萨奇病毒A组16型(Coxsachievirus A16,CVA16),A组6型(Coxsachievirus A6,CVA6),A组10型(Coxsachievirus A10,CVA10)和其它人肠道病毒(human enterovirus,HEV)核酸检测。结果785份疑似手足口病标本中,HEV总检出率为75.16%(590/785),EV 71,CVA16,CVA6,CVA10和其它HEV检出率分别为34.78%(273/785)、16.18%(127/785)、10.06%(79/785)、3.57%(28/785)和13.25%(104/785),CVA6和CVA10存在混合感染,混合感染检出率为2.68%(21/785)。不同型别的HEV流行时间存在差别。HEV阳性病例男女比例为1.53∶1(357/233),年龄以1~4岁儿童为主,散居儿童CVA6检出率高于幼托儿童,发病3 d内HEV检出率较高,为84.42%(325/385)。结论2017年渭南市手足口病主要病原体是EV 71,CVA6是非EV 71和CVA16外的其它HEV主要型别,应加强CVA6和CVA10的监测。Objective To understand pathogenic characteristics of hand-foot-mouth disease(HFMD)in Weinan and to provide etiological basis for prevention and control of HFMD by analyzing the laboratory test results for HFMD.Methods The 785 suspected HFMD specimens were subject to nucleic acid testing with respect to Enterovirus 71(EV 71),Coxsachievirus A16(CVA16),Coxsachievirus A6(CVA6),Coxsachievirus A10(CVA10)and other human enteroviruses(HEVs)using Real-time PCR(RT-PCR).Results In the 785 specimens of suspected HFMD,the total positivity rate was 75.16%(590/785)for HEV,34.78%(273/785)for EV 71,16.18%(127/785)for CVA16,10.06%(79/785)for CVA6,3.57%(28/785)for CVA10,and 13.25%(104/785)for other HEVs,and mixed infection were found with CVA6 and CVA10,and the positive of mixed infection was 2.68%(21/785).Diferent types of HEVs were found to have varied epidemic durations,the sex ratio(male to female)of HEV positive cases was 1.53∶1(357/233)and the patients mainly included children aged at 1-4 years,the positivity rate of CVA6 in diasporic children was higher than that in childcare children.The positivity rate of HEV hit 84.42%(325/385)within 3 days of onset,being higher.Conclusion Major pathogen causing HFMD in Weinan in 2017 is EV 71,CVA6 serves as main type of enterovirus es other than non-EV 71 and CVA16,the surveillance on CVA6 and CVA10 should be intensified.

关 键 词：手足口病 人肠道病毒71型 柯萨奇病毒A组6型 柯萨奇病毒A组10型 混合感染 

分 类 号：R512.5[医药卫生—内科学]