Multi-functionalized nanofibers with reactive oxygen species scavenging capability and fibrocartilage inductivity for tendon-bone integration  

作　　者：Peixing Chen Sixiang Wang Zhi Huang Yan Gao Yu Zhang Chunli Wang Tingting Xia Linhao Li Wanqian Liu Li Yang 

机构地区：[1]Key Laboratory of Biorheological Science and Technology,Ministry of Education,Bioengineering College,Chongqing University,Chongqing,400044,China [2]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing,100083,China

出　　处：《Journal of Materials Science & Technology》2021年第11期91-104,共14页材料科学技术（英文版）

基　　金：supported financially by the National Natural Science Foundation of China[No.11532004,11832008];Innovation and Attracting Talents Program for College and University(“111”Project)[No.B06023]。

摘　　要：The presence of excessive reactive oxygen species(ROS)after injuries to the enthesis could lead to cellular oxidative damage,high inflammatory response,chronic inflammation,and limited fibrochondral inductivity,making tissue repair and functional recovery difficult.Here,a multifunctional silk fibroin nanofiber modified with polydopamine and kartogenin was designed and fabricated to not only effectively reduce inflammation by scavenging ROS in the early stage of the enthesis healing but also enhance fibrocartilage formation with fibrochondrogenic induction in the later stages.The in vitro results confirmed the antioxidant capability and the fibrochondral inductivity of the functionalized nanofibers.In vivo studies showed that the multifunctional nanofiber can significantly improve the integration of tendon-bone and accelerate the regeneration of interface tissue,resulting in an excellent biomechanical property.Thus,the incorporation of antioxidant and bio-active molecules into extracellular matrix-like biomaterials in interface tissue engineering provides an integrative approach that facilitates damaged tissue regeneration and functional recovery,thereby improving the clinical outcome of the engineered tissue.

关 键 词：POLYDOPAMINE Kartogenin Tendon-bone interface Reactive oxygen species SCAVENGING Fibrochondrogenic 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]