新生小鼠心肌再生:模型与机制  

Myocardial Regeneration in Neonatal Mice:Models and Mechanisms

作　　者：向晨莹 聂宇[1] XIANG Chenying;NIE Yu(State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)

机构地区：[1]北京协和医学院,中国医学科学院阜外医院,国家心血管病中心,心血管疾病国家重点实验室,北京100037

出　　处：《中国细胞生物学学报》2021年第4期838-849,共12页Chinese Journal of Cell Biology

基　　金：中国医学科学院医学与健康科技创新工程项目(批准号:2016-I2M-1-015);国家自然科学基金(批准号:81970243、81770308)资助的课题。

摘　　要：既往的观点认为,哺乳动物的心肌受损后只能进行瘢痕修复,无法实现组织再生,最终诱发心力衰竭。近年来的大量报道则指出,哺乳动物在出生早期具备基于心肌细胞增殖的再生能力,其强度足以修复受损的心脏组织,恢复心脏的正常功能;但这一能力会在出生后早期快速丢失。新生小鼠心肌再生现象的发现,为探讨心肌再生的分子机制提供了理想的动物模型,继而有助于心肌再生修复干预靶点的开发。目前,已经广泛应用的新生小鼠心肌损伤再生模型包括:心尖切除模型、心肌梗死模型、冷冻损伤模型等。该文总结了构建新生小鼠心肌损伤后再生模型的不同方法,并综述了利用新生小鼠心肌再生模型研究取得的心肌再生机制进展。It used to be believed that the injured myocardium of mammalian could only be repaired by scar repair,which would not achieve tissue regeneration,and eventually induce heart failure.In recent years,a large number of reports have pointed out that mammals have the ability of cardiac regeneration based on the proliferation of cardiac myocytes in the early stage of life,which is strong enough to repair the damaged cardiac tissue and restore the normal function of the heart.However,this ability will be rapidly lost in the early postnatal period.The discoveries of myocardial regeneration in neonatal mice provide ideal animal models for exploring the molecular mechanisms of myocardial regeneration,and then contribute to the development of intervention targets for myocardial regeneration and repair.At present,the widely used neonatal mice models of myocardial injury and regeneration include apical resection model,myocardial infarction model,cryoinjury model,and so on.In this paper,the different methods to construct the regeneration models of neonatal mice after myocardial injury are summarized,so as the research progress of myocardial regeneration mechanisms by using neonatal mice myocardial regeneration models.

关 键 词：心脏再生 心肌损伤 心力衰竭 心肌细胞 细胞增殖 动物模型 

分 类 号：R54[医药卫生—心血管疾病]