肠道菌群在慢性疲劳综合征中的作用研究进展  

Progress in research on the role of intestinal flora in chronic fatigue syndrome

作　　者：王建楠 曾艳平[1] WANG Jian-nan;ZENG Yan-ping(Deprment of neurology,Renmin Hopial of Wahan Uniersity,Wuhan.Hubori 430060 Chima)

机构地区：[1]武汉大学人民医院,湖北武汉430060

出　　处：《中国微生态学杂志》2021年第4期478-481,486,共5页Chinese Journal of Microecology

基　　金：武汉大学自主科研项目(2042018kf0128)。

摘　　要：慢性疲劳综合征(chronic fatigue syndrome, CFS)是一种病因不明的慢性疾病,与免疫、神经炎症、感染和精神等因素有关。其临床特征主要是长期(6个月以上)的极度疲劳感伴肌肉和关节疼痛、头痛、淋巴结肿痛、喉咙痛、光敏感、直立后不适以及流感样症状等,可累及多系统。CFS诊断必须排除其他疾病,因为对CFS的病因所知甚少,并且这种疾病缺乏明确的生物标记物,所以给诊断带来一定困难。目前许多基础研究和临床研究揭示了肠道菌群失调在CFS中的具体表现,以及肠道微生态干预在缓解疲劳、睡眠和注意力障碍等症状的决定性作用。本综述复习了关于肠道菌群失调和CFS关系的研究,总结肠道菌群在CFS发病过程中的作用,明确二者之间的关系,以此来加深临床工作者对CFS的认识,便于尽早诊断,合理治疗。Chronic fatigue syndrome(CFS) is a chronic disease with unknown etiology associated with immune, neuroinflammatory, infectious and psychiatric factors. It is characterized by prolonged(6 months) periods of extreme fatigue associated with multiple system symptoms including muscle and joint pain, headache, swollen lymph nodes, sore throat, light sensitivity, posterect discomfort, and influenza-like symptoms. The diagnosis of CFS must exclude other diseases, and it is difficult because the cause of CFS is poorly understood and the disease lacks clear biomarkers. At present, many basic and clinical studies have revealed the specific manifestations of intestinal flora imbalance in CFS, as well as the deterministic role of intervention in intestinal microecology in relieving fatigue, sleep, attention disorder and other symptoms. This review reviews the research on the relationship between intestinal flora imbalance and CFS, summarizes the role of intestinal flora in the pathogenesis of CFS, and clarifies the relationship between the two, so as to deepen clinical workers′ understanding of CFS and facilitate early diagnosis and reasonable treatment.

关 键 词：肠道菌群 慢性疲劳综合征 线粒体功能障碍 生物标记物 

分 类 号：R4[医药卫生—临床医学]