Identifying the complex genetic architecture of growth and fatness traits in a Duroc pig population  

作　　者：HANG Zhe CHEN Zi-tao DIAO Shu-qi YE Shao-pan WANG Jia-ying GAO Ning YUAN Xiao-long CHEN Zan-mou ZHANG Hao LI Jia-qi 

机构地区：[1]Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding/National Engineering Research Center for Breeding Swine Industry/College of Animal Science,South China Agricultural University,Guangzhou 510642,P.R.China

出　　处：《Journal of Integrative Agriculture》2021年第6期1607-1614,共8页农业科学学报（英文版）

基　　金：the earmarked fund for China Agriculture Research System(CARS-35);the National Natural Science Foundation of China(31772556);the Key R&D Program of Guangdong Province,China(2018B020203002)。

摘　　要：In modern pig breeding programs,growth and fatness are vital economic traits that significantly influence porcine production.To identify underlying variants and candidate genes associated with growth and fatness traits,a total of 1067 genotyped Duroc pigs with de-regressed estimated breeding values(DEBV)records were analyzed in a genome wide association study(GWAS)by using a single marker regression model.In total,28 potential single nucleotide polymorphisms(SNPs)were associated with these traits of interest.Moreover,VPS4 B,PHLPP1,and some other genes were highlighted as functionally plausible candidate genes that compose the underlying genetic architecture of porcine growth and fatness traits.Our findings contribute to a better understanding of the genetic architectures underlying swine growth and fatness traits that can be potentially used in pig breeding programs.

关 键 词：PIG GWAS growth trait fatness trait candidate gene 

分 类 号：S828.2[农业科学—畜牧学]