心肌阳离子通道与再灌注性心律失常  

Myocardial cation channels and reperfusion arrhythmia

作　　者：刘小虎 秦冰杰 郑卫红[1] 张世忠[1] LIU Xiaohu;QIN Bingjie;ZHENG Weihong;ZHANG Shizhong(Medical College of China Three Gorges University,Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine,Yichang 443002,China)

机构地区：[1]三峡大学医学院,国家中药药理科研三级实验室,宜昌443002

出　　处：《生命的化学》2021年第4期664-672,共9页Chemistry of Life

摘　　要：通过溶栓和血管成形术可以恢复阻塞动脉的血流,使心肌免于最终坏死,但再灌注常诱发危及生命的心律失常,严重威胁患者的预后和健康。因此,如何有效减少心肌缺血再灌注性心律失常(reperfusion arrhythmia,RA)已成为现阶段科研和临床医生研究的热点。大量研究表明,分布于心肌细胞膜和相关细胞器的一些阳离通道参与了RA的相关病理生理过程:早期研究发现主要有NMDAR、Na^(+)、Ca^(2+)和K^(+)通道参与了RA过程。然而,研究发现,瞬时受体电位(transient receptor potential,TRP)也参与了RA过程,并可能成为RA新的药物干预靶点。因此,明确NMDAR、Na^(+)、Ca^(2+)和K^(+)及TRP等阳离子通道在RA中的病理作用能够更好地了解RA的发病机制,为其未来的临床解释、诊断及治疗提供重要的依据。Thrombolysis and angioplasty can restore the blood flow of the blocked artery and prevent the myocardium from eventual necrosis.However,reperfusion often induces life-threatening arrhythmia,which seriously threatens the prognosis and health of patients.Therefore,how to effectively reduce myocardial ischemia-reperfusion arrhythmia(RA)has become a hot spot for scientific research and clinicians at this stage.A large number of studies have shown that some cationic channels distributing on myocardial cell membranes and related organelles are involved in the pathophysiological process of RA.Early studies have found that NMDAR,Na^(+),Ca^(2+)and K^(+)channels are mainly involved in the RA process.However,studies have found that transient receptor potential(TRP)is also involved in the RA process and may become a new target for drug intervention in RA.Therefore,clarifying the pathological role of cation channels such as NMDAR,Na^(+),Ca^(2+),K^(+)and TRP in RA can better understand the pathogenesis of RA,and provide important basis for its clinical interpretation,diagnosis and treatment in the future.

关 键 词：离子通道 心肌缺血再灌注损伤 再灌注性心律失常 

分 类 号：R541.7[医药卫生—心血管疾病]