DNA数据存储技术原理及其研究进展  

Principle and Progress of DNA Data Storage

作　　者：滕越 杨姗 李金玉 崔玉军 刘芮存 王升启 TENG Yue;YANG Shan;LI Jin-Yu;CUI Yu-Jun;LIU Rui-Cun;WANG Sheng-Qi(State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China;Beijing Institute of Radiation Medicine,Beijing 100850,China)

机构地区：[1]病原微生物生物安全国家重点实验室,军事科学院军事医学研究院微生物流行病研究所,北京100071 [2]军事科学院军事医学研究院辐射医学研究所,北京100850

出　　处：《生物化学与生物物理进展》2021年第5期494-504,共11页Progress In Biochemistry and Biophysics

摘　　要：信息生产与数据存储能力之间的差距日益扩大,急需分子数据存储等高密度持久性信息保存替代方案,基于脱氧核糖核酸(DNA)的数据存储因在信息保留时间、物理密度和体积编码容量等方面优于多数传统存储介质,而广受关注.本文概述了DNA数据存储技术的基本原理,总结了体外DNA存储数据库与体内分子存储器系统的研究进展,讨论了基于DNA分子的数据存储系统所涉及的各种影响因素以及面临的挑战.The gap between information production and data storage capacity is continuously growing,so there is an urgent need for new methods of high-density,persistent data storage.With advances in DNA synthesis and sequencing,attempts have been made to use synthetic DNA for data storage and information exchange.DNA storage has many advantages compared with hard disk information storage,including high information density specificity(data bits per gram)and long storage time.Using different algorithmic strategies,text,images,audio,and movies have been encoded into synthetic DNA for storage.In addition to big data storage applications,DNA may be valuable in the exchange of classified information.This review summarizes the basic principles of DNA data storage,introduces research progress into DNA storage in vitro,and analyzes works concerning data size,logic density,and DNA synthesis.We also describe in vivo molecular memory systems,including the adoption of CRISPR to design the DNA storage system.Finally,we discuss various influencing factors and challenges of data storage systems based on DNA.

关 键 词：DNA 数据存储 细胞存储器 核酸数据库 分子计算机 

分 类 号：TP333[自动化与计算机技术—计算机系统结构] Q33[自动化与计算机技术—计算机科学与技术]