参芪复方加减治疗初诊脾虚型2型糖尿病的临床疗效及对患者生活质量和炎症因子的影响  

Clinical efficacy of Modified Shenqi Compound addition and subtraction treatment on newly diagnosed type 2 diabetes with spleen deficiency and its effect on traditional Chinese medicine syndrome,blood glucose and blood lipid

作　　者：卢昉[1] 劳美玲[1] 林俊杰[2] 魏爱生[1] 李子庆 LU Fang;LAO Meiling;LIN Junjie;WEI Aisheng;LI Ziqing(Department of Endocrinology,Foshan Hospital of TCM Affiliated to Guangzhou University of Chinese Medicine,Guangdong,Guangzhou 528000;不详)

机构地区：[1]广州中医药大学附属佛山市中医院内分泌科,广东广州528000 [2]广州中医药大学附属佛山市中医院中药房,广东广州528000

出　　处：《河北中医》2021年第2期223-227,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：广东省中医药局2015年建设中医药强省科研课题(编号:20151101)。

摘　　要：目的观察参芪复方加减治疗初诊脾虚型2型糖尿病患者的临床疗效及对患者生活质量和炎症因子的影响。方法将120例初诊脾虚型2型糖尿病患者按照随机数字表法分为2组。对照组60例予常规西药治疗,治疗组60例在对照组治疗基础上予参芪复方加减治疗。2组均治疗6周。比较2组治疗前后中医证候评分、健康调查简表(SF-36)评分、血糖[空腹血糖(FPG)、餐后2 h血糖(2 hPG)及糖化血红蛋白(HbA 1c)]、血脂[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、炎症因子[血清超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)]水平,并统计疗效。结果治疗组总有效率93.33%(56/60),对照组总有效率68.33%(41/60),治疗组疗效优于对照组(P<0.05)。治疗后2组中医证候各项评分均较本组治疗前降低(P<0.05),且治疗后治疗组均低于对照组(P<0.05)。治疗后2组SF-36各维度评分均较本组治疗前升高(P<0.05),且治疗后治疗组均高于对照组(P<0.05)。治疗后2组2 hPG、FPG及HbA 1c水平均较本组治疗前降低(P<0.05),且治疗后治疗组HbA 1c水平低于对照组(P<0.05),2 hPG、FPG水平比较差异无统计学意义(P>0.05)。治疗后2组TC、TG、LDL-C水平均较本组治疗前降低(P<0.05),HDL-C水平均升高(P<0.05),且治疗后治疗组TC、TG、LDL-C水平均低于对照组(P<0.05),HDL-C水平高于对照组(P<0.05)。治疗后2组血清hs-CRP、IL-6水平低于本组治疗前(P<0.05),且治疗后治疗组hs-CRP、IL-6水平均低于对照组(P<0.05)。结论参芪复方加减治疗初诊脾虚型2型糖尿病患者疗效确切,能有效改善患者中医证候,调节患者血糖及血脂水平,改善炎症因子水平,进而提高患者生活质量。Objective To observe the clinical efficacy of Modified Shenqi Compound addition and subtraction treatment on newly diagnosed type 2 diabetes with spleen deficiency and its effect on traditional Chinese medicine(TCM)syndrome,blood glucose and blood lipid.Methods A total of 120 patients with newly diagnosed type 2 diabetes with spleen deficiency were randomly divided into treatment group and control group,60 cases per group.The control group were received the therapy of conventional western medicine,the treatment group were received the therapy of Modified Shenqi Compound addition and subtraction on the basis of the control group,and the both groups were treated for 6 weeks.The changes of TCM syndromes score,36-Item Short-Form Health Survey(SF-36)score,blood glucose level[fasting plasma glucose(FPG),2 h postprandial glucose(2 hPG),glycosylated hemoglobin A 1c(HbA 1c)],blood lipids level[triglyceride(TG),total cholesterol(TC),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C)],serum hypersensitive c-reactive protein(hs-CRP)level and interleukin-6(IL-6)level were compared between the two groups before and after treatment,and the treatment effect was counted.Results The total effective rate in the treatment group was significantly higher than that in the control group[93.33%(56/60)vs 68.33%(41/60),(P<0.05),respectively].After treatment,the score of TCM syndromes in the two groups was significantly decreased(P<0.05),which in the treatment group was significantly lower than the control group(P<0.05);scores in each dimension of SF-36 scale in the two groups was significantly increased(P<0.05),which in the treatment group was significantly higher than the control group(P<0.05);the levels of 2 hPG,FPG and HbA 1c in the two groups were significantly decreased(P<0.05),which in the treatment group was significantly lower than the control group(P<0.05).There was no significant difference in the levels of 2 hPG and FPG between the two groups before and after treatment(P>0.05).After treatment,

关 键 词：党参 黄芪 糖尿病 2型 脾虚 中药疗法 

分 类 号：R587.105.31[医药卫生—内分泌]