21776例女性人乳头瘤病毒感染情况及亚型分布与宫颈细胞病变的相关性分析  

Correlation analysis of HPV infection and subtype distribution with cervical cytopathies in 21 776 women

作　　者：唐凤祝 简洁 梁开如[3] 罗刘衡 石艳艳[4] 余绍兰[5] 周琳琳[1] 左凤琼[1] 李婉宜[1] TANG Fengzhu;JIAN Jie;LIANG Kairu;LUO Liuheng;SHI Yanyan;YU Shaolan;ZHOU Linlin;ZUO Fengqiong;LI Wanyi(Department of Pathogenic Biology,West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu Sichuan 610041;Laboratory,Guiyang Center for Disease Control and Prevention,Guiyang Guizhou 550003;Women's Health Section,Sichuan Maternal and Child Health Hospital,Chengdu Sichuan 610031,P.R.China;Laboratory,Sichuan Maternal and Child Health Hospital,Chengdu Sichuan 610031,P.R.China;Pepartment of Pathlolgy,Sichuan Maternal and Child Health Hospital,Chengdu Sichuan 610031,P.R.China)

机构地区：[1]四川大学华西基础医学与法医学院病原生物学系,四川成都610041 [2]贵阳市疾病预防控制中心检验科,贵州贵阳550003 [3]四川省妇幼保健院妇女保健科,四川成都610031 [4]四川省妇幼保健院检验科,四川成都610031 [5]四川省妇幼保健院病理科,四川成都610031

出　　处：《中国计划生育和妇产科》2021年第5期92-96,共5页Chinese Journal of Family Planning & Gynecotokology

基　　金：四川省科技厅应用基础研究项目(项目编号:2012JY0017)。

摘　　要：目的分析四川省妇幼保健院妇科门诊21 776例女性HPV感染趋势变化以及亚型分布。方法统计分析2013年1月1日至2016年12月31日在四川省妇幼保健院妇科门诊部就诊的21 776例女性HPV感染情况及分型。结果在21 776例研究对象中,4 041例HPV检测呈阳性,感染率为18.56%,<25岁年龄组感染率最高。HPV感染中单一感染是主要感染方式(72.70%)。检出率最高的前5位亚型分别为HPV52、16、58、53、81。不同HPV亚型在不同宫颈细胞学病变级别中占比不同,HPV16在HSIL+的检出率高达72.41%。结论分析HPV感染变化趋势以及亚型分布可能会为减少宫颈癌发生提供参考。Objective To analyze the change of HPV infection trend and distribution of genotypes in the gynecological clinic of Sichuan Maternal and Child Health Hospital.Methods HPV infection status and genotypes of 21 776 women who visited the Gynecological Outpatient Department of Sichuan Maternal and Child Health Hospital from January 1,2013 to December 31,2016 were analyzed.Results Among the 21 776 study subjects, 4 041 cases were positive for HPV,the infection rate was 18.56%,and the infection rate was the highest in the age group less than 25 years old.Single infection was the main mode of infection in HPV infection(72.70%).The top 5 subtypes with the highest detection rate were HPV52,16,58,53,and 81 respectively.Different HPV subtypes accounted for different proportions in different cervical cytological lesions, and the detection rate of HPV16 in HSIL+ was as high as 72.41%.Conclusion To analyze the changing trend of HPV infection and the distribution of genotypes may provide reference for reducing the incidence of cervical cancer.

关 键 词：人乳头瘤病毒 亚型分布 宫颈细胞病变 宫颈癌 

分 类 号：R711.74[医药卫生—妇产科学]