替米沙坦联合硝苯地平控释片对糖尿病合并高血压患者血糖和炎症反应的影响  

Effect of Telmisartan Combined with Nifedipine Controlled-release Tablets on Blood Glucose and Inflammation in Patients With Diabetes and Hypertension

作　　者：王雨 钟文[2] WANG Yu;ZHONG Wen(General Department,Caoshi Yuhe Community Health Service Center of Qingyang District,Chengdu,Sichuan 610031,China;General Department,Chengdu Third People's Hospital,Chengdu,Sichuan 610014,China)

机构地区：[1]青羊区草市御河社区卫生服务中心全科,四川成都610031 [2]成都市第三人民医院全科,四川成都610014

出　　处：《大医生》2021年第3期4-6,共3页Doctor

摘　　要：目的研究替米沙坦联合硝苯地平控释片对糖尿病合并高血压患者血糖和炎症反应的影响。方法选取2018年4月至2020年6月青羊区草市御河社区卫生服务中心就诊的230例糖尿病合并高血压患者,依据随机数字表法分为对照组和试验组,各115例。对照组患者给予硝苯地平控释片治疗,试验组患者在对照组的基础上给予替米沙坦治疗,两组患者均治疗5周。比较两组患者治疗后临床疗效,治疗前后血糖水平和炎症反应的变化。结果治疗后试验组患者临床总有效率显著高于对照组:两组患者空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)水平均较治疗前显著降低(均P<0.05),两组患者治疗后各指标对比,差异均无统计学意义(均P>0.05);治疗后两组患者血清肿瘤坏死因子α(TNF-α)、C-反应蛋白(CRP)、同型半胱氨酸(Hcy)水平均较治疗前显著降低,且试验组显著低于对照组(均P<0.05)。结论替米沙坦联合硝苯地平控释片能够通过抑制炎症反应,改善糖尿病合并高血压患者血糖水平,提高临床疗效。Objective To study the effect of telmisartan combined with nifedipine controlled-release tablets on blood glucose and inflammation in patients with diabetes and hypertension.Methods 230 patients with diabetes and hypertension admitted to Caoshi Yuhe Community Health Service Center of Qingyang District from April 2018 to June 2020 were selected and divided into the control group and the test group according to the random number table,115 cases in each group.Patients in the control group were treated with nifedipine controlled-release tablets,and patients in the test group were treated with telmisartan on the basis of the control group.Patients in both groups were treated for 5 weeks.Compared the clinical efficacy of the two groups of patients after treatment^the changes in blood glucose levels and inflammation before and after treatment.Results After treatment,the total clinical effective rate of the test group was significantly higher than that of the control group;the fasting blood glucose(FPG):2 h postprandial blood glucose(2 h PG),and glycosylated hemoglobin(HbAlc)levels of the two groups were all significantly lower than before treatment(all P<0.05);after treatment,there was no statistically difference in the comparison of each index between the two groups(all P>0.05);ater treatment,the serum tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and homocysteine(Hey)levels of the two groups of patients were lower than before treatment,and the test group was lower than the control group(all P<0.05).Conclusion Telmisartan combined with nifedipine controlled-release tablets can improve the blood glucose level of patients with diabetes and hypertension by inhibiting the inflammatory response,and improve clinical efficacy.

关 键 词：糖尿病合并高血压 替米沙坦 硝苯地平控释片 血糖 炎症反应 

分 类 号：R587.2[医药卫生—内分泌]