Small scale adeno-associated virusvector production for preclinical gene delivery based on chloroform precipitation  

作　　者：Marcus Davidsson Andreas Heuer 

机构地区：[1]Molecular Neuromodulation,Department of Experimental Medical Sciences,Lund University,Lund,Sweden [2]Behavioural Neuroscience Laboratory,Department of Experimental Medical Sciences,Lund University,Lund,Sweden

出　　处：《Neural Regeneration Research》2022年第1期99-100,共2页中国神经再生研究（英文版）

基　　金：supported by the Royal Physiographic Society of Lund(Kungliga Fysiografiska sallskapet);the royal Swedish academy of sciences(Kungliga Vetenskapsakademien);the Per-Eric och Ulla Schybergs foundation(to MD);the Swedish Research Council(Vetenskapsradet);the Parkinsons foundation(Parkinsonsfonden);the Ahlens foundation(Ahlensstiftelsen);the Jeanssons foundation(Jeanssons stiftelser)as well as the Crafoord foundation(Crafoordska stiftelsen)(to AH)。

摘　　要：Gene therapy aims to introduce genetic information into a cell-type of interest to replace,correct,silence,or modify defective genes.Gene therapy in its broadest sense can theoretically prevent,halt,or cure any condition that affects mankind.In addition to that,the introduction and/or manipulation of genes is one of the major research areas in biological sciences,aimed to deepen our knowledge on how biological systems work.Scientific advances have made it possible to induce changes ranging from manipulations of large stretches of the genome to the change of single nucleotides.The gold-standard vehicles to bring this genetic information into the target cells are viral vectors.

关 键 词：replace SMALL mankind 

分 类 号：R450[医药卫生—治疗学]